2型糖尿病患者睡眠时间与肥胖之间的关联：一项纵向研究。

Association between sleep duration and obesity in patients with type 2 diabetes: A longitudinal study.

作者信息

Makhdom Esraa A, Maher Alisha, Ottridge Ryan, Nicholls Mathew, Ali Asad, Cooper Brendan G, Ajjan Ramzi A, Bellary Srikanth, Hanif Wasim, Hanna Fahmy, Hughes David, Jayagopal Vijay, Mahto Rajni, Patel Mayank, Young James, Nayak Ananth U, Chen Mimi Z, Kyaw-Tun Julie, Gonzalez Susana, Gouni Ravikanth, Subramanian Anuradhaa, Adderley Nicola J, Tahrani Abd A

机构信息

Department of Metabolism and Systems Science, University of Birmingham, Birmingham, UK.

Department of Respiratory Care, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.

出版信息

Diabet Med. 2025 Jun;42(6):e70051. doi: 10.1111/dme.70051. Epub 2025 Apr 17.

DOI:10.1111/dme.70051

PMID:40247658

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12080980/

Abstract

BACKGROUND

Obesity is prevalent in patients with type 2 diabetes (T2D) and negatively impacts diabetes outcomes. While studies in the general population have established a link between sleep duration and obesity, this relationship in T2D remains unclear.

OBJECTIVES

To assess the association between sleep duration and adiposity in patients with T2D.

METHODS

This prospective study of adults enrolled in the SLEEP T2D study from 13 UK NHS Trusts. Sleep duration was self-reported using the Pittsburgh Sleep Quality Index (PSQI) and categorized as short (≤ 6 h/ night), long (> 9 h/night) or (normal > 6-9 h/night). Adiposity was assessed using body mass index (BMI) and waist circumference.

RESULTS

Among 229 patients (61% male, mean age 61.2 ( 11.7) years, 63.7% with BMI ≥ 30 kg/m). At baseline, sleep duration negatively correlated with BMI (r = -0.27, p < 0.001) and waist circumference (r = -0.25, p = 0.001). After adjusting for potential confounders in different models, short sleep duration was associated with higher BMI (β = -1.01; p = 0.006) and waist circumference (β = -1.91; p = 0.01). Following a median follow-up of 26.5 months, short sleep at baseline was associated with a 5% or more gain in BMI (adjusted OR 10.03; 95% CI 1.55-64.84; p = 0.01).

CONCLUSION

Short sleep duration is associated with higher adiposity measures (BMI and waist circumference) and weight gain in patients with T2D. Addressing sleep duration may reduce the burden of obesity in T2D, and future studies in this area are warranted.

摘要

背景

肥胖在2型糖尿病（T2D）患者中普遍存在，且对糖尿病病情转归有负面影响。虽然普通人群研究已证实睡眠时间与肥胖之间存在关联，但T2D患者中的这种关系仍不明确。

目的

评估T2D患者睡眠时间与肥胖的关联。

方法

这是一项对来自英国13家国民保健服务（NHS）信托机构参与SLEEP T2D研究的成年人进行的前瞻性研究。睡眠时间通过匹兹堡睡眠质量指数（PSQI）进行自我报告，并分为短睡眠（≤6小时/晚）、长睡眠（>9小时/晚）或正常睡眠（>6 - 9小时/晚）。肥胖程度通过体重指数（BMI）和腰围进行评估。

结果

共纳入229例患者（61%为男性，平均年龄61.2（±11.7）岁，63.7%的患者BMI≥30kg/m²）。基线时，睡眠时间与BMI呈负相关（r = -0.27，p < 0.001），与腰围也呈负相关（r = -0.25，p = 0.001）。在不同模型中对潜在混杂因素进行校正后，短睡眠时间与较高的BMI（β = -1.01；p = 0.006）和腰围（β = -1.91；p = 0.01）相关。中位随访26.5个月后，基线时的短睡眠时间与BMI增加5%或更多相关（校正后OR 10.03；95%CI 1.55 - 64.84；p = 0.01）。