Pancreatitis Center, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA.
Division of Gastroenterology, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA.
Am J Gastroenterol. 2021 Oct 1;116(10):2026-2028. doi: 10.14309/ajg.0000000000001491.
Pain perception in chronic pancreatitis (CP) is governed by the transmission of nociceptive inputs into the pain processing centers of the brain. These regions of the brain overlap with those that regulate and process emotions and cognition. Disorders in these regions also result in psychiatric conditions such as depression, anxiety, and posttraumatic stress disorder. The present study by Dunbar et al. evaluated 24 single nucleotide polymorphisms associated with anxiety and/or posttraumatic stress disorder and found correlations with constant and severe pain phenotypes in CP patients from a large cross-sectional cohort study. Although causation cannot be proven, the findings suggest that there may be a role for neuromodulator drugs for the treatment of pain in CP based on individual genetic susceptibility.
慢性胰腺炎（CP）的疼痛感知由伤害性传入信息传递到大脑的疼痛处理中枢控制。大脑的这些区域与调节和处理情绪和认知的区域重叠。这些区域的紊乱也会导致精神疾病，如抑郁症、焦虑症和创伤后应激障碍。Dunbar 等人的这项研究评估了与焦虑和/或创伤后应激障碍相关的 24 个单核苷酸多态性，并在一项大型横断面队列研究中发现了与 CP 患者的持续和严重疼痛表型的相关性。虽然不能证明因果关系，但这些发现表明，根据个体的遗传易感性，神经调节剂药物可能在 CP 疼痛的治疗中发挥作用。
