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基因编码 TRPV1 受体的多态性与疼痛感知有关，但与慢性胰腺炎无关。

Polymorphisms in gene encoding TRPV1-receptor involved in pain perception are unrelated to chronic pancreatitis.

机构信息

Department of Gastroenterology & Hepatology, Radboud University Nijmegen Medical Centre, The Netherlands.

出版信息

BMC Gastroenterol. 2009 Dec 24;9:97. doi: 10.1186/1471-230X-9-97.

DOI:10.1186/1471-230X-9-97
PMID:20034385
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2813232/
Abstract

BACKGROUND

The major clinical feature in chronic pancreatitis is pain, but the genetic basis of pancreatic pain in chronic pancreatitis is poorly understood. The transient receptor potential vanilloid receptor 1 (TRPV1) gene has been associated with pain perception, and genetic variations in TRPV1 may modify the presence and phenotype of chronic pancreatitis. The aim of our study was to investigate the genetic variation of TRPV1 in Dutch patients with chronic pancreatitis and healthy controls.

METHODS

We genotyped 4 SNPs (rs222749, rs222747, rs224534 and rs8065080) in 228 chronic pancreatitis-patients and 207 healthy controls by PCR, followed by restriction-fragment-length-polymorphism analysis and DNA sequencing. We generated 27 diplotypes and compared prevalence between patients and controls.

RESULTS

There was no significant difference in allele frequency of the 4 TRPV1 gene SNPs in patients with chronic pancreatitis and healthy controls. Distribution of diplotypes was not statistically significantly different between patients and controls.

CONCLUSION

TRPV1 diplotypes are not associated with chronic pancreatitis.

摘要

背景

慢性胰腺炎的主要临床特征是疼痛，但慢性胰腺炎中胰腺疼痛的遗传基础知之甚少。瞬时受体电位香草素受体 1（TRPV1）基因与疼痛感知有关，TRPV1 的遗传变异可能会改变慢性胰腺炎的存在和表型。我们的研究旨在研究荷兰慢性胰腺炎患者和健康对照者 TRPV1 的遗传变异。

方法

我们通过 PCR 对 228 例慢性胰腺炎患者和 207 例健康对照者的 4 个单核苷酸多态性（rs222749、rs222747、rs224534 和 rs8065080）进行了基因分型，然后进行限制性片段长度多态性分析和 DNA 测序。我们生成了 27 种二倍型，并比较了患者和对照组之间的患病率。

结果

慢性胰腺炎患者和健康对照组 TRPV1 基因 4 个 SNP 的等位基因频率无显著差异。患者和对照组之间二倍型的分布无统计学差异。

结论

TRPV1 二倍型与慢性胰腺炎无关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/332a/2813232/155a277b49e2/1471-230X-9-97-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/332a/2813232/c2bd88565c6f/1471-230X-9-97-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/332a/2813232/2a0a8aef60b3/1471-230X-9-97-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/332a/2813232/155a277b49e2/1471-230X-9-97-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/332a/2813232/c2bd88565c6f/1471-230X-9-97-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/332a/2813232/2a0a8aef60b3/1471-230X-9-97-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/332a/2813232/155a277b49e2/1471-230X-9-97-3.jpg

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