听力恢复和血管纹：免疫系统在听力恢复中的作用的证据。
Hearing restoration and the stria vascularis: evidence for the role of the immune system in hearing restoration.
机构信息
Georgetown University School of Medicine.
Department of Otolaryngology-Head and Neck Surgery, Georgetown University School of Medicine, MedStar Georgetown University Hospital, Washington, District of Columbia.
出版信息
Curr Opin Otolaryngol Head Neck Surg. 2021 Oct 1;29(5):373-384. doi: 10.1097/MOO.0000000000000738.
PURPOSE OF REVIEW
This article reviews the current literature regarding the pathogenesis of immune-mediated sensorineural hearing loss, utilizes previously published single-nucleus transcriptional profiles to characterize cytokine and cytokine receptor expression in the adult stria vascularis cell types to support immune system interaction with the stria vascularis and reviews the current literature on immunomodulatory agents currently being used for hearing-restoration treatment.
RECENT FINDINGS
The literature review highlights recent studies that elucidate many cytokines and immune markers, which have been linked to various immune-mediated disease processes that have been observed with sensorineural hearing loss within the stria vascularis and highlights recent publications studying therapeutic targets for these pathways.
SUMMARY
This review highlights the current literature regarding the pathogenesis of immune-mediated hearing loss. The role of cochlear structures in human temporal bones from patients with immune-mediated sensorineural hearing loss are highlighted, and we review cytokine signalling pathways relevant to immune-mediated sensorineural hearing loss and localize genes encoding both cytokine and cytokine receptors involved in these pathways. Finally, we review immunomodulatory therapeutics in light of these findings and point to opportunities for the application of novel therapeutics by targeting these signalling pathways.
目的综述
本文综述了目前关于免疫介导的感音神经性听力损失发病机制的文献，利用先前发表的单核细胞转录谱特征，描述成年血管纹细胞类型中细胞因子和细胞因子受体的表达，以支持免疫系统与血管纹的相互作用，并综述目前用于听力恢复治疗的免疫调节药物的相关文献。
最近发现
文献综述强调了最近的研究，这些研究阐明了许多细胞因子和免疫标志物，这些标志物与血管纹中观察到的各种与免疫相关的疾病过程有关，这些疾病与感音神经性听力损失有关，并强调了最近研究这些途径治疗靶点的出版物。
总结
本文综述了目前关于免疫介导的听力损失发病机制的文献。本文强调了人类颞骨中耳蜗结构在免疫介导的感音神经性听力损失患者中的作用，我们综述了与免疫介导的感音神经性听力损失相关的细胞因子信号通路，并定位了参与这些通路的细胞因子和细胞因子受体的编码基因。最后，我们根据这些发现综述了免疫调节治疗，并指出通过靶向这些信号通路应用新型治疗方法的机会。
Zotero 插件