Section of Eating Disorders, Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Eur Eat Disord Rev. 2021 Nov;29(6):969-984. doi: 10.1002/erv.2859. Epub 2021 Aug 30.
This study explored participants' experience of approach bias modification training (ABM) with transcranial Direct Current Stimulation (tDCS) for binge eating disorder (BED) within a randomised controlled trial (RCT). A subset of participants who completed the RCT were interviewed to attain feedback on treatment experience and outcomes.
15 participants with BED who completed the RCT were recruited, using purposive sampling. Participants received six sessions of concurrent ABM training with either real or sham tDCS. Semi-structured interviews relating to study experience and treatment outcomes were conducted and data were analysed thematically.
The combined ABM and tDCS intervention was deemed acceptable and worthwhile by participants interviewed across both intervention groups. Negative preconceptions of tDCS were an initial deterrent to study participation for some, yet the brain stimulation experience was found to be tolerable. Minor and transient sensations and side effects attributed to tDCS were reported by most participants during and after stimulation, in addition to less pleasant aspects of ABM training, with no significant adverse effects reported by interviewees. Positive outcomes were described by participants across both intervention groups, relating to changes in BED symptoms and to broader beneficial effects on associated cognitive and emotional factors. Two participants experienced a shift in autonomy, attributed to tDCS and the combined intervention respectively.
Adults with symptoms of BED found concurrent ABM and tDCS sessions to be acceptable, despite initial apprehension about the safety of tDCS. Findings are relevant to the neuroethics literature and may inform science communication strategies on neuromodulation treatments.
本研究通过随机对照试验（RCT）探索参与者接受经颅直流电刺激（tDCS）辅助的趋近偏差修正训练（ABM）治疗暴食障碍（BED）的体验。对完成 RCT 的一部分参与者进行访谈，以获得关于治疗体验和结果的反馈。
使用目的抽样法招募了 15 名完成 RCT 的 BED 参与者。参与者接受了六次 ABM 训练与真实或假 tDCS 联合治疗。对与研究经验和治疗结果相关的半结构化访谈进行了访谈，并进行了主题分析。
接受访谈的两组参与者都认为联合 ABM 和 tDCS 的干预措施是可接受的和有价值的。对 tDCS 的负面先入为主观念最初对一些参与者参与研究构成了障碍，但大脑刺激体验被发现是可以忍受的。大多数参与者在刺激期间和之后报告了轻微的、短暂的感觉和副作用，并归因于 tDCS，除了 ABM 训练中不那么愉快的方面外，没有报告任何明显的不良反应。两组参与者都描述了积极的结果，涉及 BED 症状的变化以及对相关认知和情绪因素的更广泛的有益影响。两名参与者分别归因于 tDCS 和联合干预而体验到自主性的转变。
有 BED 症状的成年人发现同时进行 ABM 和 tDCS 治疗是可以接受的，尽管对 tDCS 的安全性最初存在担忧。研究结果与神经伦理学文献相关，并可能为神经调节治疗的科学传播策略提供信息。
