Division of Cardiology, Department of Medicine Solna, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden.
Division of Vascular Surgery, Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden.
Curr Opin Pharmacol. 2021 Oct;60:183-192. doi: 10.1016/j.coph.2021.07.022. Epub 2021 Aug 27.
Diets containing nutrients such as polyunsaturated fatty acids, polyphenols, or vitamins have been shown to have cardiovascular benefits. Micro (mi)RNAs are fundamental regulators of gene expression and function in the cardiovascular system. Diet-induced cardiovascular benefits are associated with changes in endogenous expression of miRNAs in the cardiovascular system. In addition, emerging studies have shown that miRNAs present in the food can be transported in the circulation to tissues. These exogenous miRNAs may also affect cardiovascular function contributing to the diet-induced benefits. This review discusses the emerging role of both endogenous and exogenous miRNAs as mediators of diet-induced cardiovascular protection. Understanding the mechanisms of diet-mediated actions through modulation of miRNA may provide a potential strategy for new therapies.
含有多不饱和脂肪酸、多酚或维生素等营养物质的饮食已被证明对心血管有好处。microRNAs (miRNAs) 是心血管系统中基因表达和功能的基本调节因子。饮食诱导的心血管益处与心血管系统中内源性 miRNA 表达的变化有关。此外，新兴的研究表明，食物中存在的 miRNAs 可以在循环中被运输到组织中。这些外源性 miRNAs 也可能影响心血管功能，从而促进饮食诱导的益处。本文综述了内源性和外源性 miRNAs 作为饮食诱导心血管保护的中介物的新作用。通过调节 miRNA 来理解饮食介导作用的机制可能为新的治疗策略提供一种潜在的方法。
