双曲紧束缚抑制的图形与统计分析
Graphical and statistical analysis of hyperbolic tight-binding inhibition.
作者信息
Baici A
机构信息
Department of Rheumatology, University Hospital, Zurich, Switzerland.
出版信息
Biochem J. 1987 Jun 15;244(3):793-6. doi: 10.1042/bj2440793.
Abstract
Equations are described for the analysis of enzyme-catalysed reactions in the presence of hyperbolic tight-binding inhibitors using both graphical and non-linear-regression methods. The general character of the equations allows the interpretation of several other kinetic mechanisms. As an example, the tight-binding hyperbolic non-competitive inhibition of human leucocyte elastase by a polysulphated glycosaminoglycan is analysed.
摘要
本文描述了使用图形法和非线性回归法分析在双曲线型紧密结合抑制剂存在下酶催化反应的方程式。这些方程式的一般特性允许解释其他几种动力学机制。作为一个例子，分析了一种多硫酸化糖胺聚糖对人白细胞弹性蛋白酶的紧密结合双曲线型非竞争性抑制作用。
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引用本文的文献
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Inhibition of leucocyte elastase by heparin and its derivatives.肝素及其衍生物对白细胞弹性蛋白酶的抑制作用。
Biochem J. 1988 Jun 1;252(2):515-9. doi: 10.1042/bj2520515.
2
A re-evaluation of the kinetic equations for hyperbolic tight-binding inhibition.对双曲线紧密结合抑制动力学方程的重新评估。
Biochem J. 1988 Aug 15;254(1):311-2. doi: 10.1042/bj2540311.
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Enzyme inhibition in relation to chemotherapy.与化疗相关的酶抑制作用。
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The specific velocity plot. A graphical method for determining inhibition parameters for both linear and hyperbolic enzyme inhibitors.特定速度图。一种用于确定线性和双曲线型酶抑制剂抑制参数的图形方法。
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Inhibition of human elastase from polymorphonuclear leucocytes by a glycosaminoglycan polysulfate (Arteparon).一种糖胺聚糖多硫酸盐（Arteparon）对多形核白细胞来源的人弹性蛋白酶的抑制作用。
Biochem Pharmacol. 1980 Jun 15;29(12):1723-7. doi: 10.1016/0006-2952(80)90131-8.
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Further studies on elastase-like esterases in human leukocyte granules.关于人白细胞颗粒中类弹性蛋白酶酯酶的进一步研究。
Proc Soc Exp Biol Med. 1971 Apr;136(4):1045-9. doi: 10.3181/00379727-136-35424.
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Kinetics of the reversible inhibition of enzyme-catalysed reactions by tight-binding inhibitors.紧密结合抑制剂对酶催化反应的可逆抑制动力学。
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The statistical analysis of enzyme kinetic data.酶动力学数据的统计分析。
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