溴化乙锭对丁酰胆碱酯酶的抑制作用。
Inhibition of the butyrylcholinesterase by ethidium bromide.
作者信息
Patocka J
机构信息
Purknyĕ Medical Research Institute, Hradec Králové, Czechoslovakia.
出版信息
Biomed Biochim Acta. 1987;46(11):769-74.
PMID:3446203
Abstract
The effect of ethidium bromide (3,8-diamino-5-ethyl-6-phenyl-phenanthridinium bromide) on the activity of purified horse serum butyrylcholinesterase in vitro has been studied. Ethidium bromide is a middle reversible inhibitor with complex mixed competitive-noncompetitive inhibition kinetics. The inhibitor is bound to the anionic site of the enzyme surface.
摘要
研究了溴化乙锭（3,8 - 二氨基 - 5 - 乙基 - 6 - 苯基菲啶溴化物）对纯化的马血清丁酰胆碱酯酶体外活性的影响。溴化乙锭是一种具有复杂混合竞争 - 非竞争抑制动力学的中度可逆抑制剂。该抑制剂与酶表面的阴离子位点结合。
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