Ohara K, Takeshima T
Department of Radiology, University of Tsukuba, Ibaraki, Japan.
Acta Oncol. 1987;26(6):459-62. doi: 10.3109/02841868709113718.
Tolerance of surgical portal vein anastomosis to intraoperative radiation therapy (IORT) was studied in dogs after single doses of zero, 10, 20 and 40 Gy (290 kVp x-rays). Portal venography was performed prior to IORT and before sacrificing. The dogs were sacrificed 3 and 12 months respectively after irradiation. Portal venography revealed no radiation induced anastomotic stenosis. Autopsy disclosed macroscopic periportal fibrosis in all dogs, independent of radiation dose and observation periods. Microscopically, the three tunicas of the vein did not show any pathological changes after any dose level.
在犬类动物中研究了手术门静脉吻合术对术中放射治疗（IORT）的耐受性，给予单次剂量为0、10、20和40 Gy（290 kVp X射线）的照射。在IORT之前和处死前进行门静脉造影。照射后分别在3个月和12个月处死犬类。门静脉造影显示无放射诱导的吻合口狭窄。尸检发现所有犬类均有肉眼可见的门静脉周围纤维化，与放射剂量和观察期无关。显微镜检查显示，在任何剂量水平下，静脉的三层膜均未出现任何病理变化。
