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VEXAS syndrome with systemic lupus erythematosus: expanding the spectrum of associated conditions.伴有系统性红斑狼疮的VEXAS综合征：扩展相关疾病谱
Arthritis Rheumatol. 2022 Feb;74(2):369-371. doi: 10.1002/art.41957. Epub 2021 Dec 27.
2
Lupus mastitis heralding systemic lupus erythematosus with antiphospholipid syndrome.狼疮性乳腺炎预示着系统性红斑狼疮合并抗磷脂综合征。
J Rheumatol. 1993 Jul;20(7):1217-20.
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[Pulmonary thromboembolism associated with antiphospholipid syndrome and systemic lupus erythematosus].
Rev Med Chil. 2000 Aug;128(8):899-903.
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Comparison of renal disease severity and outcome in patients with primary antiphospholipid syndrome, antiphospholipid syndrome secondary to systemic lupus erythematosus (SLE) and SLE alone.原发性抗磷脂综合征、系统性红斑狼疮（SLE）继发抗磷脂综合征及单纯SLE患者的肾脏疾病严重程度和预后比较。
Rheumatology (Oxford). 2001 Aug;40(8):863-7. doi: 10.1093/rheumatology/40.8.863.
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Systemic lupus erythematosus and antiphospholipid antibody syndrome associated Addison disease: A case report.系统性红斑狼疮和抗磷脂抗体综合征相关艾迪生病：一例报告。
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2021 Jul 28;46(7):780-784. doi: 10.11817/j.issn.1672-7347.2021.200758.
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Antiphospholipid antibodies and non-thrombotic manifestations of systemic lupus erythematosus.抗磷脂抗体与系统性红斑狼疮的非血栓形成表现
Lupus. 2018 Apr;27(4):665-669. doi: 10.1177/0961203317734924. Epub 2017 Oct 19.
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Stroke in systemic lupus erythematosus and antiphospholipid syndrome: risk factors, clinical manifestations, neuroimaging, and treatment.系统性红斑狼疮和抗磷脂综合征中的中风：危险因素、临床表现、神经影像学及治疗
Lupus. 2017 Apr;26(5):529-536. doi: 10.1177/0961203316688784.
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Cardiac valve involvement in systemic lupus erythematosus and primary antiphospholipid syndrome: lack of correlation with antiphospholipid antibodies.心脏瓣膜受累于系统性红斑狼疮和原发性抗磷脂综合征：与抗磷脂抗体缺乏相关性。
Int J Cardiol. 1995 Sep;51(2):117-26. doi: 10.1016/0167-5273(95)02357-3.
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[Systemic lupus erythematosus and antiphospholipid syndrome: How to manage pregnancy?].[系统性红斑狼疮与抗磷脂综合征：如何管理妊娠？]
Rev Med Interne. 2015 Mar;36(3):173-81. doi: 10.1016/j.revmed.2014.12.005. Epub 2015 Jan 8.
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Aortoarteritis with systemic lupus erythematosus and secondary antiphospholipid antibody syndrome: a rare association.大动脉炎合并系统性红斑狼疮及继发性抗磷脂抗体综合征：一种罕见的关联。
Indian Heart J. 2002 May-Jun;54(3):301-3.

引用本文的文献

1
Clinical features in VEXAS syndrome: a systematic review.VEXAS综合征的临床特征：一项系统评价
Rheumatology (Oxford). 2025 Oct 1;64(10):5217-5229. doi: 10.1093/rheumatology/keaf293.
2
In depth transcriptomic profiling defines a landscape of dysfunctional immune responses in patients with VEXAS syndrome.深度转录组分析描绘了VEXAS综合征患者功能失调的免疫反应图景。
Nat Commun. 2025 May 20;16(1):4690. doi: 10.1038/s41467-025-59890-0.
3
Clinical features and treatments of VEXAS syndrome in critical care: a scoping review.危重症护理中VEXAS综合征的临床特征与治疗：一项范围综述
Crit Care. 2025 Apr 17;29(1):154. doi: 10.1186/s13054-025-05390-y.
4
Altered IgG4 serum levels in VEXAS syndrome - a retrospective monocentric cohort study.VEXAS综合征中IgG4血清水平的改变——一项回顾性单中心队列研究。
Rheumatol Int. 2025 Mar 22;45(4):79. doi: 10.1007/s00296-025-05824-4.
5
Targeting enhanced cell death represents a potential therapeutic strategy for VEXAS syndrome.靶向增强细胞死亡是治疗VEXAS综合征的一种潜在策略。
Rheumatol Adv Pract. 2024 May 22;8(2):rkae065. doi: 10.1093/rap/rkae065. eCollection 2024.
6
VEXAS syndrome presenting as diffuse alveolar haemorrhage.VEXAS 综合征表现为弥漫性肺泡出血。
BMJ Case Rep. 2024 Mar 27;17(3):e259474. doi: 10.1136/bcr-2023-259474.
7
VEXAS syndrome: Current clinical, diagnostic and treatment approaches.VEXAS综合征：当前的临床、诊断及治疗方法
Intractable Rare Dis Res. 2023 Aug;12(3):170-179. doi: 10.5582/irdr.2023.01020.
8
Early activation of inflammatory pathways in UBA1-mutated hematopoietic stem and progenitor cells in VEXAS.UBA1 突变的造血干细胞和祖细胞中 VEXAS 炎症途径的早期激活。
Cell Rep Med. 2023 Aug 15;4(8):101160. doi: 10.1016/j.xcrm.2023.101160.
9
Novel causative variants of VEXAS in UBA1 detected through whole genome transcriptome sequencing in a large cohort of hematological malignancies.通过对一大组血液系统恶性肿瘤进行全基因组转录组测序，发现了 UBA1 中新型的 VEXAS 致病变异体。
Leukemia. 2023 May;37(5):1080-1091. doi: 10.1038/s41375-023-01857-5. Epub 2023 Feb 23.
10
Pulmonary manifestations in VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome: a systematic review.VEXAS（空泡、E1 酶、X 连锁、自身炎症、体细胞）综合征的肺部表现：系统评价。
Rheumatol Int. 2023 Jun;43(6):1023-1032. doi: 10.1007/s00296-022-05266-2. Epub 2023 Jan 8.

本文引用的文献

1
Somatic Mutations in and Severe Adult-Onset Autoinflammatory Disease.和严重成人发病的自身炎症性疾病中的体细胞突变。
N Engl J Med. 2020 Dec 31;383(27):2628-2638. doi: 10.1056/NEJMoa2026834. Epub 2020 Oct 27.

VEXAS syndrome with systemic lupus erythematosus: expanding the spectrum of associated conditions.

作者信息

Sharma Aman, Naidu Gsrsnk, Deo Prateek, Beck David B

机构信息

Post Graduate Institute of Medical Education and Research, Chandigarh, India.

National Human Genome Research Institute NIH, Bethesda, MD.

出版信息

Arthritis Rheumatol. 2022 Feb;74(2):369-371. doi: 10.1002/art.41957. Epub 2021 Dec 27.

DOI:10.1002/art.41957
PMID:34463053
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8795469/
Abstract
摘要