Department of Physical Education & Sport Sciences, Faculty of Sport Science, Islamic Azad University, Tehran, Iran.
Tarbiat Modares University, Tehran, Iran.
J Complement Integr Med. 2021 Jun 23;19(2):305-310. doi: 10.1515/jcim-2021-0103. eCollection 2022 Jun 1.
This animal study aimed to demonstrate the synergistic effect of high-intensity interval training (HIIT) and alcoholic extract of nettle on serum chemerin and beta cells function in type 2 diabetic male rats.
Thirty-two STZ-induced diabetic male Wistar rats were randomly divided into four groups including the control group, the supplemented group with 200 mg/day of nettle, the training group with five sessions per week of HIIT, and the group with combined nettle and HITT intervention. Body weight, lipid profile, beta cells function, and chemerin level were assessed after eight weeks of the intervention.
The values of chemerin significantly decreased in combined HIIT and nettle intervention group compared to the control group (p=0.001). The levels of glucose and insulin decreased significantly in nettle group, exercise group, and combined HIIT and nettle group (p=0.001).
The present study found that intense interval exercise with the consumption of alcoholic extract of nettle can affect the performance of beta cells, glucose, and insulin. Future human studies are warranted.
本动物研究旨在证明高强度间歇训练（HIIT）和荨麻醇提物对 2 型糖尿病雄性大鼠血清趋化因子和β细胞功能的协同作用。
32 只 STZ 诱导的糖尿病雄性 Wistar 大鼠随机分为四组，包括对照组、每天 200mg 荨麻补充组、每周 5 次 HIIT 训练组和 HIIT 与荨麻联合干预组。干预 8 周后评估体重、血脂谱、β细胞功能和趋化因子水平。
与对照组相比，联合 HIIT 和荨麻干预组的趋化因子值显著降低（p=0.001）。荨麻组、运动组和 HIIT 与荨麻联合干预组的血糖和胰岛素水平显著降低（p=0.001）。
本研究发现，高强度间歇运动结合荨麻醇提物的摄入会影响β细胞、葡萄糖和胰岛素的功能。需要进一步开展人类研究。
