Wang Xiao-Feng, Cao Wen-Bin, Li Hai-Yan, Xu Xiao-Ping, Ji Shun-Jun
Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science & Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou 215123, P. R. China.
Analysis and Testing Center, Soochow University, Suzhou 215123, China.
J Org Chem. 2021 Sep 17;86(18):12597-12606. doi: 10.1021/acs.joc.1c01054. Epub 2021 Aug 31.
A one-step cascade reaction of tryptamine-derived isocyanides with generated nitrile oxides for the synthesis of fused spiroindolines was described. The desired products could be efficiently synthesized in moderate to good yields (42-87%). The protocol features mild conditions, wide substrate scope, and high efficiency.
描述了一种由色胺衍生的异腈与生成的腈氧化物进行的一步串联反应，用于合成稠合螺吲哚啉。所需产物能够以中等至良好的产率（42-87%）高效合成。该方法具有条件温和、底物范围广和效率高的特点。
