Department of Radiology, Nanjing First Hospital, Nanjing Medical University, No.68, Changle Road, 210006, Nanjing, China.
Department of Neurology, Nanjing Yuhua Hospital, Yuhua Branch of Nanjing First Hospital, 210006, Nanjing, China.
Clin Neuroradiol. 2022 Mar;32(1):205-214. doi: 10.1007/s00062-021-01082-6. Epub 2021 Aug 31.
This study aimed to investigate differences in static and dynamic functional network connectivity (FNC) and explore their association with neurocognitive performance in acute mild traumatic brain injury (mTBI).
A total of 76 patients with acute mTBI and 70 age-matched and sex-matched healthy controls were enrolled (age 43.79 ± 10.22 years vs. 45.63 ± 9.49 years; male/female: 34/42 vs. 38/32; all p > 0.05) and underwent resting-state functional magnetic resonance imaging (fMRI) scan (repetition time/echo time = 2000/30 ms, 230 volumes). Independent component analysis was conducted to evaluate static and dynamic FNC patterns on the basis of nine resting-state networks, namely, auditory network (AUDN), dorsal attention network (dAN), ventral attention network (vAN), default mode network (DMN), left frontoparietal network (LFPN), right frontoparietal network (RFPN), somatomotor network (SMN), visual network (VN), and salience network (SN). Spearman's correlation among aberrances in FNC values, and Montreal cognitive assessment (MoCA) scores was further measured in mTBI.
Compared with controls, patients with mTBI showed wide aberrances of static FNC, such as reduced FNC in DMN-vAN and VN-vAN pairs. The mTBI patients exhibited aberrant dynamic FNC in state 2, involving reduced FNC aberrance in the vAN with AUDN, VN with DMN and dAN, and SN with SMN and vAN. Reduced dFNC in the SN-vAN pair was negatively correlated with the MoCA score.
Our findings suggest that aberrant static and dynamic FNC at the acute stage may contribute to cognitive symptoms, which not only may expand knowledge regarding FNC cognition relations from the static perspective but also from the dynamic perspective.
本研究旨在探讨急性轻度创伤性脑损伤（mTBI）患者静息态和动态功能网络连接（FNC）的差异，并探索其与神经认知表现的关系。
共纳入 76 例急性 mTBI 患者和 70 例年龄和性别匹配的健康对照者（年龄 43.79±10.22 岁比 45.63±9.49 岁；男/女：34/42 比 38/32；均 P＞0.05），并接受静息态功能磁共振成像（fMRI）扫描（重复时间/回波时间=2000/30ms，230 个容积）。基于九个静息态网络（听觉网络（AUDN）、背侧注意网络（dAN）、腹侧注意网络（vAN）、默认模式网络（DMN）、左侧额顶网络（LFPN）、右侧额顶网络（RFPN）、躯体运动网络（SMN）、视觉网络（VN）和突显网络（SN））进行独立成分分析，以评估静息态和动态 FNC 模式。进一步在 mTBI 患者中测量 FNC 值和蒙特利尔认知评估（MoCA）评分之间的异常变化的 Spearman 相关性。
与对照组相比，mTBI 患者的静息态 FNC 存在广泛的异常，如 DMN-vAN 和 VN-vAN 对之间的 FNC 降低。mTBI 患者在状态 2 中表现出异常的动态 FNC，涉及 AUDN 与 vAN、VN 与 DMN 和 dAN、SN 与 SMN 和 vAN 之间的 FNC 降低。SN-vAN 对之间的 dFNC 降低与 MoCA 评分呈负相关。
我们的研究结果表明，急性阶段异常的静息态和动态 FNC 可能导致认知症状，这不仅可能从静息态角度扩展 FNC 与认知关系的知识，还可能从动态角度扩展。
