Medical Physics Department, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom.
Phys Med Biol. 2021 Sep 16;66(18). doi: 10.1088/1361-6560/ac2266.
The radiance equation is applied in this study to model the ultraviolet (UV) radiation dose distribution over the skin in paediatric and adult patients treated in a whole-body phototherapy cabin. This approach extends a previously published model of UV radiation dose based on thermal radiation exchange between surfaces (Coleman2020055023). The new model makes it feasible to predict the distribution of UV irradiance over the head, trunk and legs in patients of varying height. The modelled irradiance distributions to directly lamp-facing skin surfaces agree to within 10% of those measured in simulated clinical paediatric treatments in a modern narrowband UVB treatment cabin. For a 10 year old (of height 1.36 m), for example, the model and the clinical measurements both show a UV radiation dose to the face that is around 25% more than that in an adult (of height 1.8 m). The dose to the crown of the head of a 10 year old is both predicted and measured to be more than double that of an adult. The automated dosimetry system, incorporated within the treatment cabin, is also predicted to overestimate irradiance to the body by between 10% and 25% in patients aged between 10 and 4 years (height 1.36-1.0 m). The value of the model and its implications for paediatric whole-body UV treatment in adult-size whole-body treatment cabins are considered.
本研究应用辐射度方程来模拟全身光疗舱中治疗的儿科和成年患者皮肤的紫外线(UV)辐射剂量分布。这种方法扩展了先前基于表面之间热辐射交换的 UV 辐射剂量模型(Coleman2020055023)。新模型使得预测不同身高患者头部、躯干和腿部的 UV 辐照度分布成为可能。直接面向灯管的皮肤表面的模拟辐照度分布与在现代窄带 UVB 治疗舱中模拟临床儿科治疗中测量的结果相差在 10%以内。例如,对于一个 10 岁(身高 1.36 米)的儿童,模型和临床测量都显示面部的 UV 辐射剂量比成人(身高 1.8 米)高约 25%。10 岁儿童头顶的剂量被预测和测量都超过成人的两倍。治疗舱内包含的自动剂量计系统也被预测会高估 10 至 4 岁(身高 1.36-1.0 米)患者的身体辐照度,误差在 10%至 25%之间。考虑了模型的价值及其对成人尺寸全身治疗舱中儿科全身 UV 治疗的影响。