Anvari Kazem, Majidi Mohammad Reza, Razmara Ferezghi Mahdi, Parkam Bahereh, Javadinia Seyed Alireza
Cancer Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Ear, Nose, Throat Research Center, Ghaem Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Galen Med J. 2018 Dec 31;7:e860. doi: 10.22086/gmj.v0i0.860. eCollection 2018.
Malignant melanoma (MM) usually present with metastases to unexpected regions of the body. Metastatic MM is a highly lethal condition, and the median survival in this setting is 6 to 7.5 months; however, few reports rarely describe long-term after chemotherapy.
We describe a 31-year-old man with MM, which got metastatic (to paranasal sinuses) after local and systemic therapy showed complete responses with long-term survival after endonasal endoscopic metastasectomy and radiotherapy of the nasal cavity, paranasal sinuses, and base of the skull.
Although long-term survival is rare, few reports describe cases after chemotherapy. MM could be associated with metastasis to any regions and clinicians should be aware of its behavior and perform complete investigation in the presence of any suspicious symptoms, and this should be reinforced periodically. However, the survival is poor in the metastatic setting, and the treatment of choice is debatable, some patients may benefit from metastasectomy and local radiotherapy.
恶性黑色素瘤（MM）通常会出现转移至身体意外部位的情况。转移性MM是一种高度致命的疾病，这种情况下的中位生存期为6至7.5个月；然而，很少有报告描述化疗后的长期情况。
我们描述了一名31岁的MM男性患者，在局部和全身治疗显示完全缓解后发生转移（至鼻窦），在内鼻内镜下进行鼻窦、鼻腔和颅底转移灶切除及放疗后长期存活。
虽然长期生存罕见，但很少有报告描述化疗后的病例。MM可转移至任何部位，临床医生应了解其行为，并在出现任何可疑症状时进行全面检查，且应定期强化检查。然而，转移性情况下生存率较低，治疗选择存在争议，一些患者可能从转移灶切除和局部放疗中获益。
