Giotakis Aris I, Natsiopoulou Ourania, Bouka Eleni, Riga Dimitra, Lygeros Spyridon, Giotakis Evangelos
First Department of Otorhinolaryngology, Hippocration General Hospital Athens, Medical University of Athens, National and Kapodistrian University of Athens, Athens, GRC.
Department of Pathology, Hippocration General Hospital, Athens, Athens, GRC.
Cureus. 2024 Oct 18;16(10):e71792. doi: 10.7759/cureus.71792. eCollection 2024 Oct.
Metastases of cutaneous melanoma to the paranasal sinuses and nasopharynx are considered rare. We reported the case of a patient with cutaneous melanoma metastasizing to the left anterior infundibulum and seven months later to the right nasopharynx that was successfully treated by endonasal endoscopic surgery as a single treatment modality. No adjuvant radiotherapy was performed. We described all known cases of metastatic cutaneous melanomas to the paranasal sinuses and nasopharynx. In cases of neither lung involvement nor open foramen ovale, the metastatic route might be the vertebral venous system. The histopathologic differentiation between primary mucosal and metastatic cutaneous melanoma remains critical. Adequate surgical treatment is crucial. More data are needed to further understand the role of adjuvant radiotherapy. Molecular markers, such as KIT and BRAF mutations, should be examined.
皮肤黑色素瘤转移至鼻窦和鼻咽部被认为较为罕见。我们报告了一例皮肤黑色素瘤患者，该肿瘤转移至左侧前漏斗部，七个月后转移至右侧鼻咽部，通过鼻内镜手术作为单一治疗方式成功治疗。未进行辅助放疗。我们描述了所有已知的皮肤黑色素瘤转移至鼻窦和鼻咽部的病例。在既无肺部受累也无卵圆孔开放的情况下，转移途径可能是椎静脉系统。原发性黏膜黑色素瘤和转移性皮肤黑色素瘤的组织病理学鉴别仍然至关重要。充分的手术治疗至关重要。需要更多数据来进一步了解辅助放疗的作用。应检测分子标志物，如KIT和BRAF突变。
