Anvari Seyyed Saeid, Nasehi Mohammad, Zarrindast Mohammad-Reza
Institute for Cognitive Science Studies (ICSS), Tehran, Iran.
Cognitive and Neuroscience Research Center (CNRC), Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
Galen Med J. 2019 Jun 16;8:e1157. doi: 10.31661/gmj.v8i0.1157. eCollection 2019.
The endogenous opioid system plays a basic role in pain suppression. The opiate analgesia is the most powerful and useful technique for reducing severe pain in many medical conditions. Transcranial direct current stimulation (tDCS) is a neuromodulator technique by which the cerebral cortex is stimulated with a weak and constant electrical current by the painless and non-invasive method.
In this experimental study, we investigated the effect of tDCS on morphine (1.25, 2.5 and 5 mg/kg)-induced pain responses; as we applied left prefrontal anodal stimulation with 0.2 mA intensity and 20 minutes.
our results revealed that the acute (One-time electrical stimulation 24 hours after the last administration of morphine three days) and subchronic (three times electrical stimulation; one session/day before each administration of morphine three days) left prefrontal anodal tDCS does not alter pain perception induced by different dose of morphine significantly.
Finally, our data indicated that there is no potentiated effect between acute tDCS or subchronic tDCS and morphine administration with tested parameters significantly.
内源性阿片系统在疼痛抑制中起基本作用。阿片类镇痛是在许多医疗状况下减轻剧痛最有效且有用的技术。经颅直流电刺激（tDCS）是一种神经调节技术，通过无痛且非侵入性的方法用微弱且恒定的电流刺激大脑皮层。
在本实验研究中，我们研究了tDCS对吗啡（1.25、2.5和5毫克/千克）诱导的疼痛反应的影响；我们以0.2毫安强度和20分钟进行左侧前额叶阳极刺激。
我们的结果显示，急性（在最后一次给予吗啡三天后24小时进行一次性电刺激）和亚慢性（三次电刺激；在三天内每次给予吗啡前每天进行一次）左侧前额叶阳极tDCS并未显著改变不同剂量吗啡诱导的疼痛感知。
最后，我们的数据表明，在所测试参数下，急性tDCS或亚慢性tDCS与吗啡给药之间不存在显著的增强效应。
