Vakilian Alireza, Fekri Mohaddaseh, Farahmand Habib
Neurology Department, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Non-Communicable Diseases Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Galen Med J. 2019 Jan 1;8:e1357. doi: 10.31661/gmj.v8i0.1357. eCollection 2019.
Creutzfeldt-Jakob disease (CJD) is a progressive and fatal prion disease in human and its annual incidence is estimated one per million. Sporadic form of CJD is the most common form of the disease that involved 85% of cases.
We presented two cases of CJD with the different clinical presentation; a 58-year-old woman who referred with amnesia, depression and a 59-year-old woman with ataxia as her chief complaint. Based on the findings and roled-out the other differential diagnosis, the CJD was confirmed. Both of them died before 12 months after diagnosis.
Although CJD is a rare disease with different clinical manifestation, it is considered as one the differential diagnosis of progressive dementia.
克雅氏病（CJD）是一种人类进行性致命性朊病毒病，其年发病率估计为百万分之一。散发性克雅氏病是该疾病最常见的形式，占病例的85%。
我们报告了两例临床表现不同的克雅氏病病例；一例是一名58岁女性，以失忆、抑郁为症状前来就诊，另一例是一名59岁女性，以共济失调为主要诉求。根据检查结果并排除了其他鉴别诊断后，确诊为克雅氏病。两人均在诊断后12个月内死亡。
尽管克雅氏病是一种临床表现各异的罕见疾病，但它被认为是进行性痴呆的鉴别诊断之一。
