Guerrero Gustavo, Le Rolle Virginie, Hernández Alfredo
Univ Rennes, Inserm, LTSI - UMR 1099, Campus de Beaulieu, Bât 22, 35042, Rennes, France.
Ann Biomed Eng. 2021 Dec;49(12):3374-3387. doi: 10.1007/s10439-021-02828-6. Epub 2021 Aug 31.
An original integrated model of cardio-respiratory interactions is presented in this paper with the objective of studying the acute physiological responses evoked by obstructive sleep apnea events in adults. A comprehensive sensitivity analysis of the model is proposed during the simulation of a 20 s obstructive apnea episode using the Morris' screening method and local sensitivity analysis. The more relevant parameters are related to the following mechanisms of the physiology: (i) the fraction of oxygen in inspired air, (ii) metabolic rates (oxygen consumption rate, CO production rate); (iii) chemoreflex (gains and time constants) (iv) respiratory mechanics (lung compliance and unstressed volume of air in the alveoli). These results highlight significant physiological variables that may be particularly useful for the development of novel diagnostic and therapeutic strategies, integrating a virtual patient approach.
本文提出了一种心肺相互作用的原始综合模型，目的是研究成人阻塞性睡眠呼吸暂停事件引发的急性生理反应。在使用莫里斯筛选法和局部敏感性分析对20秒的阻塞性呼吸暂停发作进行模拟期间，对该模型进行了全面的敏感性分析。更相关的参数与以下生理机制有关：（i）吸入空气中的氧气分数；（ii）代谢率（耗氧率、CO产生率）；（iii）化学反射（增益和时间常数）；（iv）呼吸力学（肺顺应性和肺泡中无应力空气量）。这些结果突出了重要的生理变量，这些变量对于整合虚拟患者方法的新型诊断和治疗策略的开发可能特别有用。
