Univ Rennes, CHU Rennes, Inserm, LTSI - UMR 1099, F-35000 Rennes, France.
Univ Rennes, CHU Rennes, Inserm, LTSI - UMR 1099, F-35000 Rennes, France.
Comput Biol Med. 2024 May;173:108343. doi: 10.1016/j.compbiomed.2024.108343. Epub 2024 Mar 18.
The analysis of the complex interactions involved in the acute physiological response to apnea-bradycardia events in preterm newborns remains a challenging task. This paper presents a novel integrated model of cardio-respiratory interactions, adapted to preterm newborns. A sensitivity analysis, based Morris' screening method, was applied to study the effects of physiological parameters on heart rate and desaturation, during the simulation of a 15-seconds apnea-bradycardia episode. The most sensitive parameters are associated with fundamental, integrative physiological mechanisms involving: (i) respiratory mechanics (intermediate airways and lung compliance), (ii) fraction of inspired oxygen, (iii) metabolic rates (oxygen consumption rate), (iv) heart rate regulation and (v) chemoreflex (gain). Results highlight the relevant influence of physiological variables, involved in preterm apnea-bradycardia events.
分析早产儿呼吸暂停-心动过缓事件中涉及的复杂相互作用仍然是一项具有挑战性的任务。本文提出了一种新的适应早产儿的心肺相互作用综合模型。基于 Morris 筛选法的敏感性分析被应用于研究在模拟 15 秒呼吸暂停-心动过缓事件期间，生理参数对心率和饱和度的影响。最敏感的参数与涉及以下基本综合生理机制的参数有关：（i）呼吸力学（中间气道和肺顺应性），（ii）吸入氧气分数，（iii）代谢率（耗氧量），（iv）心率调节和（v）化学反射（增益）。结果突出了与早产儿呼吸暂停-心动过缓事件相关的生理变量的重要影响。
