The First Clinical Medical Collage of Lanzhou University.
School of life science, Lanzhou University.
Biol Pharm Bull. 2021 Nov 1;44(11):1724-1731. doi: 10.1248/bpb.b21-00443. Epub 2021 Sep 2.
Salidroside is reported to have a wide range of pharmacological properties and has been proven to play a key anti-cancer effect. This study investigated the effects of purified salidroside, an ingredient of Rhodiola rosea, on the proliferation of two human gastric cancer cell lines and further investigating its possible molecular mechanisms. We verified that salidroside exerts a dose-dependent inhibitory effect on the proliferation of SGC-7901 and MKN-45 human gastric cancer cells. Moreover, salidroside can induce cell apoptosis, which was accompanied by an increase in nuclear fragmentation. In addition, salidroside inhibited glycolysis, as evidenced by the reduced expression levels of the glycolysis-related enzymes pyruvate kinase isoenzyme M2 (PKM2), enolase 1 (ENO1) and glucose transporter 1 (GLUT1), which could play important roles in the metabolism of gastric cancer cells. Further investigation showed that salidroside exerted potent anti-proliferative effects by inhibiting glycolysis in human gastric cancer cells in vitro. In vivo, xenograft tumors treated with salidroside were significantly smaller than those in the control animals. Therefore, salidroside could be a promising therapeutic prospect in the treatment of gastric cancer.
红景天苷被报道具有广泛的药理作用，并已被证明具有关键的抗癌作用。本研究探讨了红景天中一种成分——纯化红景天苷对两种人胃癌细胞系增殖的影响，并进一步研究了其可能的分子机制。我们验证了红景天苷对 SGC-7901 和 MKN-45 人胃癌细胞的增殖具有剂量依赖性抑制作用。此外，红景天苷可诱导细胞凋亡，伴有核片段化增加。此外，红景天苷抑制糖酵解，这表现在糖酵解相关酶丙酮酸激酶同工酶 M2（PKM2）、烯醇酶 1（ENO1）和葡萄糖转运蛋白 1（GLUT1）的表达水平降低，这可能在胃癌细胞的代谢中发挥重要作用。进一步的研究表明，红景天苷通过抑制人胃癌细胞中的糖酵解在体外发挥强大的抗增殖作用。在体内，用红景天苷处理的异种移植肿瘤明显小于对照组动物的肿瘤。因此，红景天苷可能是治疗胃癌的一种有前途的治疗前景。
