Institute of Pharmaceutical Technologies, Faculty of Pharmacy, Medical Academy, Lithuanian University of Health Sciences, Sukileliu pr. 13, LT-50161 Kaunas, Lithuania.
Department of Drug Technology and Social Pharmacy, Faculty of Pharmacy, Medical Academy, Lithuanian University of Health Sciences, Sukileliu pr. 13, LT-50161 Kaunas, Lithuania.
Int J Mol Sci. 2023 Jul 31;24(15):12293. doi: 10.3390/ijms241512293.
The roots and rhizomes of L. (Crassulaceae), which is widely growing in Northern Europe, North America, and Siberia, have been used since ancient times to alleviate stress, fatigue, and mental and physical disorders. Phenolic compounds: phenylpropanoids rosavin, rosarin, and rosin, tyrosol glucoside salidroside, and tyrosol, are responsible for the biological action of , exerting antioxidant, immunomodulatory, anti-aging, anti-fatigue activities. extract formulations are used as alternative remedies to enhance mental and cognitive functions and protect the central nervous system and heart during stress. Recent studies indicate that may be used to treat diabetes, cancer, and a variety of cardiovascular and neurological disorders such as Alzheimer's and Parkinson's diseases. This paper reviews the beneficial effects of the extract of , its key active components, and their possible use in the treatment of chronic diseases. represents an excellent natural remedy to address situations involving decreased performance, such as fatigue and a sense of weakness, particularly in the context of chronic diseases. Given the significance of mitochondria in cellular energy metabolism and their vulnerability to reactive oxygen species, future research should prioritize investigating the potential effects of main bioactive phenolic compounds on mitochondria, thus targeting cellular energy supply and countering oxidative stress-related effects.
皱叶酸模（蓼科）的根和根茎在北欧、北美和西伯利亚广泛生长，自古以来就被用于缓解压力、疲劳以及精神和身体障碍。酚类化合物：苯丙素类化合物 rosavin、rosarin 和松香，酪醇葡萄糖苷 salidroside 和酪醇，负责 的生物学作用，发挥抗氧化、免疫调节、抗衰老、抗疲劳作用。 的提取物制剂被用作替代疗法，以增强精神和认知功能，并在压力下保护中枢神经系统和心脏。最近的研究表明， 可能用于治疗糖尿病、癌症以及各种心血管和神经紊乱，如阿尔茨海默病和帕金森病。本文综述了 的提取物、其关键活性成分的有益作用及其在治疗慢性疾病中的可能用途。 在涉及表现下降的情况下，例如疲劳和虚弱感， 代表了一种极好的天然疗法，特别是在慢性疾病的背景下。鉴于线粒体在细胞能量代谢中的重要性及其对活性氧的脆弱性，未来的研究应优先调查 的主要生物活性酚类化合物对线粒体的潜在影响，从而靶向细胞能量供应并对抗与氧化应激相关的影响。
