Heilongjiang University of Chinese Medicine, Harbin, China.
Hongqi Hospital of Mudanjiang Medical University, Mudanjiang, China.
Integr Cancer Ther. 2024 Jan-Dec;23:15347354241302049. doi: 10.1177/15347354241302049.
Gastrointestinal (GI) cancer stands as one of the most prevalent forms of cancer globally, presenting a substantial medical and economic burden on cancer treatment. Despite advancements in therapies, it continues to exhibit the second highest mortality rate, primarily attributed to drug resistance and post-treatment side effects. There is an urgent need for novel therapeutic approaches to tackle this persistent challenge. , widely used in Traditional Chinese Medicine (TCM), holds a profound pharmaceutical legacy. Modern pharmacological studies have unveiled its anticancer, antioxidant, and immune-enhancing properties. contains hundreds of active ingredients, with flavonoids, polysaccharides, phenylethanoid glycosides, terpenoids, and sterols being the principal components. These constituents contribute to the treatment of GI cancer by inducing apoptosis in tumor cells, arresting the cell cycle, inhibiting tumor proliferation and metastasis, regulating the tumor microenvironment, modulating epigenetics, and reversing drug resistance. Furthermore, the utilization of modern drug delivery technologies can enhance the bioavailability and therapeutic efficacy of TCM. The treatment of GI cancer with is characterized by its multi-component, multi-target, and multi-pathway advantages, and has a broad prospect of becoming a clinical adjuvant or even the main therapy for GI cancer.
胃肠道（GI）癌症是全球最常见的癌症形式之一，对癌症治疗造成了巨大的医疗和经济负担。尽管治疗方法有所进步，但它仍然是死亡率第二高的癌症，主要归因于耐药性和治疗后副作用。因此，迫切需要新的治疗方法来应对这一持续存在的挑战。 ，广泛应用于传统中药（TCM），拥有深厚的医药遗产。现代药理学研究揭示了其抗癌、抗氧化和增强免疫力的特性。 含有数百种活性成分，主要成分包括类黄酮、多糖、苯乙醇苷、萜类和甾体。这些成分通过诱导肿瘤细胞凋亡、阻止细胞周期、抑制肿瘤增殖和转移、调节肿瘤微环境、调节表观遗传学和逆转耐药性来治疗胃肠道癌症。此外，现代药物输送技术的应用可以提高中药的生物利用度和治疗效果。 治疗胃肠道癌症具有多成分、多靶点、多途径的优势，有望成为胃肠道癌症的临床辅助治疗甚至主要治疗方法。
