Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore.
Singapore Immunology Network, A*STAR, Singapore, Singapore.
Cell Mol Immunol. 2021 Oct;18(10):2307-2312. doi: 10.1038/s41423-021-00743-3. Epub 2021 Sep 1.
During viral infections, antibodies and T cells act together to prevent pathogen spread and remove virus-infected cells. Virus-specific adaptive immunity can, however, also trigger pathological processes characterized by localized or systemic inflammatory events. The protective and/or pathological role of virus-specific T cells in SARS-CoV-2 infection has been the focus of many studies in COVID-19 patients and in vaccinated individuals. Here, we review the works that have elucidated the function of SARS-CoV-2-specific T cells in patients and in vaccinated individuals. Understanding whether SARS-CoV-2-specific T cells are more linked to protection or pathogenesis is pivotal to define future therapeutic and prophylactic strategies to manage the current pandemic.
在病毒感染期间，抗体和 T 细胞共同作用以防止病原体传播和清除病毒感染的细胞。然而，病毒特异性适应性免疫也可以引发以局部或全身炎症事件为特征的病理过程。在 COVID-19 患者和接种疫苗的个体中，SARS-CoV-2 感染中病毒特异性 T 细胞的保护和/或病理作用一直是许多研究的重点。在这里，我们综述了阐明 SARS-CoV-2 特异性 T 细胞在患者和接种疫苗个体中的功能的研究。了解 SARS-CoV-2 特异性 T 细胞与保护还是发病机制的关系更为密切，对于确定管理当前大流行的未来治疗和预防策略至关重要。
