Huang Ling, Liu Jiahui, Zhu Yi, Zhou Quan, Xiao Bin, Sun Zhaohui, Li Linhai
Department of Laboratory Medicine, General Hospital of Southern Theatre Command of PLA, Guangzhou 510010, Guangdong, China.
Sheng Wu Gong Cheng Xue Bao. 2021 Aug 25;37(8):2595-2602. doi: 10.13345/j.cjb.200488.
Nuclear receptor subfamily 2, group F, member 6 (NR2F6) is a member of orphan nuclear receptors, which is expressed in major tissues and organs of the human body, and plays an important role in the regulation of various biological functions and gene expressions. Recent studies have shown that the expression of NR2F6 was up-regulated in a variety of malignant tumors and showed significant correlations with cancer progression. These findings triggered the widespread interest in understanding the relationship between NR2F6 and cancer development and progression. In addition, the latest studies have underscored that NR2F6 was involved in enhancing antitumor immune responses that could serve as a potential target for immune regulation. This review summarizes the biological functions of NR2F6 and its role in tumors, with the aim to provide new insights into effective cancer therapies.
核受体亚家族2，F组成员6（NR2F6）是孤儿核受体的成员之一，在人体的主要组织和器官中表达，并在各种生物学功能和基因表达的调节中发挥重要作用。最近的研究表明，NR2F6在多种恶性肿瘤中表达上调，且与癌症进展显著相关。这些发现引发了人们对理解NR2F6与癌症发生发展关系的广泛兴趣。此外，最新研究强调，NR2F6参与增强抗肿瘤免疫反应，可作为免疫调节的潜在靶点。本综述总结了NR2F6的生物学功能及其在肿瘤中的作用，旨在为有效的癌症治疗提供新的见解。
