Institute of Physics, Academia Sinica, 128 Academia Road Sec. 2, Taipei 11529, Taiwan.
National Synchrotron Radiation Research Center, Hsinchu 30076, Taiwan.
J Synchrotron Radiat. 2021 Sep 1;28(Pt 5):1662-1668. doi: 10.1107/S1600577521007633. Epub 2021 Aug 23.
The new Brain Imaging Beamline (BIB) of the Taiwan Photon Source (TPS) has been commissioned and opened to users. The BIB and in particular its endstation are designed to take advantage of bright unmonochromatized synchrotron X-rays and target fast 3D imaging, ∼1 ms exposure time plus very high ∼0.3 µm spatial resolution. A critical step in achieving the planned performances was the solution to the X-ray induced damaging problems of the detection system. High-energy photons were identified as their principal cause and were solved by combining tailored filters/attenuators and a high-energy cut-off mirror. This enabled the tomography acquisition throughput to reach >1 mm min, a critical performance for large-animal brain mapping and a vital mission of the beamline.
台湾光子源（TPS）的新脑成像光束线（BIB）已投入使用并向用户开放。BIB，特别是其末端站，旨在利用明亮的非单色同步加速器 X 射线，并以快速的 3D 成像为目标，曝光时间约为 1ms，空间分辨率非常高，约为 0.3μm。实现计划性能的关键步骤是解决检测系统的 X 射线诱导损伤问题。高能光子被确定为其主要原因，并通过组合定制的滤波器/衰减器和高能截止镜来解决。这使得断层扫描采集速度达到了>1mm/min，这对于大型动物大脑映射是一个关键性能，也是光束线的一个重要任务。
