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[儿童血液系统疾病中的脾动脉栓塞术]

[Splenic artery embolization in hematologic diseases in children].

作者信息

Ionescu G O, Daniil C

机构信息

Clinique de chirurgie Infantile et d'orthopédie de Iagi, Roumanie.

出版信息

Chir Pediatr. 1987;28(6):285-9.

PMID:3447767
Abstract

In the past four years or so splenectomy used in children with hematological defects, who showed hypersplenism has been replaced with partial arterial splenic embolization (Pase), in general, 2/3 of the lower spleen were embolized. Pase was performed after the selective catheterization of the splenic artery up to the hilum with local anesthesia. As an embolizing agent, with the first 2 patients a suspension of Gelaspon microparticles and absolute alcohol (90 degrees) was used, and with the others (7 patients with 9 embolizations) only absolute alcohol. The Pase indication was: congenital hemolytic anemia in 5 cases; thrombocytopenia in 3 cases (5 pase); portal hypertension by extra-hepatic blockage with secondary hypersplenism in one case where the endoscopic sclerosis of the esophageal varices had been done first, followed by Pase after weeks. The evolution after Pase was simple in 6 patients: fever, pain in the left hypochondrium, and moderate ileus for 2-3 days. In 3 cases the evolution was both complicated and difficult excessive Pase in the first 2 patients, that practically resulted in total splenectomy, and, in the other one, the growth of a big subcapsular hematoma with effusion that had to be eliminated through transparietal drainage, under echographic control and operated secondary for peritonitis. Hematologically, in all cases but one (1 failure) hypersplenism remission was obtained and the results are the same 1-3 years after Pase. Partial arterial splenic embolization can very well replace splenectomy in hematological defects manifested as hypersplenism. The use of absolute alcohol (90 degrees) as an excellent embolization agent has not been reported so far in children.

摘要

在过去大约四年中,用于患有血液系统缺陷且表现为脾功能亢进的儿童的脾切除术已被部分脾动脉栓塞术(Pase)所取代,一般栓塞脾脏下2/3的部分。Pase在局部麻醉下经选择性脾动脉插管至脾门后进行。作为栓塞剂,最初2例患者使用明胶海绵微粒与无水乙醇(90度)的混悬液,其他患者(7例进行了9次栓塞)仅使用无水乙醇。Pase的适应证为:5例先天性溶血性贫血;3例血小板减少症(5次Pase);1例肝外阻塞性门静脉高压伴继发性脾功能亢进,该例患者先进行了内镜下食管静脉曲张硬化治疗,数周后进行Pase。6例患者Pase后的病情发展较简单:发热、左季肋部疼痛,以及2 - 3天的中度肠梗阻。3例患者的病情发展既复杂又困难:最初2例患者Pase过度,实际上导致了全脾切除术,另一例患者出现巨大的包膜下血肿并伴有积液,必须在超声引导下经皮引流清除,随后因腹膜炎进行二期手术。血液学方面,除1例(1次失败)外,所有病例的脾功能亢进均得到缓解,Pase后1 - 3年的结果相同。部分脾动脉栓塞术能够很好地替代在表现为脾功能亢进的血液系统缺陷中使用的脾切除术。使用无水乙醇(90度)作为一种优良的栓塞剂在儿童中迄今尚未见报道。

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1
[Splenic artery embolization in hematologic diseases in children].[儿童血液系统疾病中的脾动脉栓塞术]
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Medicina (B Aires). 2003;63(3):224-6.