Department of Animal Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran.
Stem Cell and Regenerative Medicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran.
J Gastrointest Cancer. 2022 Sep;53(3):687-691. doi: 10.1007/s12029-021-00686-y. Epub 2021 Sep 3.
Gastric cancer (GC) is one of the most frequent tumors worldwide and identification of a sensitive and specific prognostic biomarker is of great importance. Long non-coding RNAs (lncRNAs) play crucial roles in tumorigenesis of various malignancies. In the present study, we investigated lncRNA FOXD2-AS1 expression in gastric tumors and assessed its potential as a prognostic biomarker.
A total of 95 tumor and corresponding adjacent non-tumor tissue specimens were collected from patients with GC from Imam Reza hospital, Tabriz, Iran. Total RNA was isolated and FOXD2-AS1 expression was measured using quantitative reverse transcriptase (qRT)-PCR.
FOXD2-AS1 was significantly upregulated in tumor samples as compared to non-tumor tissues (P < 0.0001). In addition, higher expression of FOXD2-AS1 was significantly associated with lymph node metastasis and Helicobacter pylori infection. The receiver operating characteristic (ROC) curve analysis revealed that FOXD2-AS1 might be served as a potential prognostic biomarker for GC.
FOXD2-AS1 is upregulated in gastric tumors and can be used as a valuable biomarker in the prognosis of patients with GC.
胃癌（GC）是全球最常见的肿瘤之一，因此确定一种敏感且特异的预后生物标志物具有重要意义。长链非编码 RNA（lncRNA）在多种恶性肿瘤的发生中发挥着关键作用。本研究旨在探讨 lncRNA FOXD2-AS1 在胃癌肿瘤中的表达情况，并评估其作为预后生物标志物的潜力。
从伊朗大不里士伊玛目礼萨医院的 GC 患者中收集了 95 例肿瘤和相应的癌旁非肿瘤组织标本。使用定量逆转录（qRT）-PCR 方法测定总 RNA 中 FOXD2-AS1 的表达水平。
FOXD2-AS1 在肿瘤组织中的表达明显高于非肿瘤组织（P<0.0001）。此外，FOXD2-AS1 的高表达与淋巴结转移和幽门螺杆菌感染显著相关。受试者工作特征（ROC）曲线分析表明，FOXD2-AS1 可能作为 GC 的潜在预后生物标志物。
FOXD2-AS1 在胃癌肿瘤中上调，可作为 GC 患者预后的有价值的生物标志物。
