Molebatsi Keneilwe, Ng Lauren C, Chiliza Bonginkosi
Department of Psychiatry, Nelson R. Mandela School of Clinical Medicine, University of KwaZulu-Natal, Durban, South Africa.
Department of Psychiatry, Faculty of Medicine, University of Botswana, Private Bag, 00713, Gaborone, Botswana.
Pilot Feasibility Stud. 2021 Sep 3;7(1):170. doi: 10.1186/s40814-021-00904-1.
Research consistently reports elevated rates of exposure to traumatic events and post-traumatic stress disorder (PTSD) in people with severe mental illness (SMI). PTSD may be adequately managed with psychotherapy; however, there is a gap when it comes to management in culturally diverse settings like Botswana. This paper describes a study protocol whose aim is to culturally adapt the BREATHE intervention, a brief psychological intervention for people living with comorbid PTSD and SMI that was developed and tested in the USA; assess the feasibility and acceptability of the adapted BREATHE intervention and explore its efficacy.
The study will be conducted in three phases using a mixed methods approach. The first phase will identify and describe the most common traumatic experiences and responses to traumatic experiences, amongst patients with SMI, and patients' and mental health care providers' perceptions about suitable PTSD interventions for Botswana. The second phase will entail cultural adaption of the intervention using findings from phase 1, and the third phase will be a pilot trial to assess the feasibility and acceptability of the culturally adapted intervention and explore its efficacy. Quantitative and qualitative data will be analysed using basic descriptive statistics and thematic analysis, respectively.
Literature highlights cultural variations in the expression and management of mental illness suggesting the need for culturally adapted interventions. The findings of this feasibility study will be used to inform the design of a larger trial to assess the efficacy of an adapted brief intervention for PTSD in patients with SMI in Botswana.
Clinicaltrials.gov registration: NCT04426448 . Date of registration: June 7, 2020.
研究一直报告称，严重精神疾病（SMI）患者遭受创伤性事件和创伤后应激障碍（PTSD）的比例有所上升。PTSD可以通过心理治疗得到有效管理；然而，在博茨瓦纳这样文化多元的环境中，管理方面存在差距。本文描述了一项研究方案，其目的是对BREATHE干预措施进行文化适应性调整，BREATHE是一种针对患有PTSD和SMI合并症的人群的简短心理干预措施，在美国开发并进行了测试；评估调整后的BREATHE干预措施的可行性和可接受性，并探索其疗效。
该研究将采用混合方法分三个阶段进行。第一阶段将识别并描述SMI患者中最常见的创伤经历以及对创伤经历的反应，以及患者和精神卫生保健提供者对博茨瓦纳合适的PTSD干预措施的看法。第二阶段将利用第一阶段的研究结果对干预措施进行文化适应性调整，第三阶段将进行一项试点试验，以评估文化适应性干预措施的可行性和可接受性，并探索其疗效。定量和定性数据将分别使用基本描述性统计和主题分析进行分析。
文献强调了精神疾病表达和管理方面的文化差异，这表明需要进行文化适应性干预。这项可行性研究的结果将用于为一项更大规模试验的设计提供信息，以评估针对博茨瓦纳SMI患者的PTSD适应性简短干预措施的疗效。
Clinicaltrials.gov注册编号：NCT04426448。注册日期：2020年6月7日。
