Baylor College of Medicine, Department of Pediatrics, United States; Section of Pediatric Infectious Diseases, United States.
University of Florida, Department of Pharmacy, United States.
J Cyst Fibros. 2022 Mar;21(2):348-352. doi: 10.1016/j.jcf.2021.08.010. Epub 2021 Sep 1.
Few studies have evaluated clofazimine (CLOF) drug monitoring and safety in children. We treated 10 children, 8 with CF, for NTM infection with multiple antimicrobials, including CLOF. All had serial blood CLOF concentrations measured and were followed for adverse events. Despite CLOF dose escalation, most children with CF did not reach a target CLOF concentration. Our data suggest that children with CF may require earlier initiation of CLOF at higher doses than is currently recommended.
鲜有研究评估过氯法齐明（CLOF）的药物监测和儿童用药安全性。我们用包括氯法齐明在内的多种抗生素治疗了 10 名儿童，其中 8 名为 CF 患者，治疗非结核分枝杆菌感染。所有患者都进行了连续的血液氯法齐明浓度检测，并观察不良事件。尽管增加了氯法齐明的剂量，但大多数 CF 患儿仍未达到目标浓度。我们的数据表明，CF 患儿可能需要比目前建议的更早开始更高剂量的氯法齐明治疗。
