School of Population Health, Faculty of Health Sciences, Curtin University, Perth, WA, 6845, Australia.
Institute for Resilient Regions, University of Southern Queensland, Springfield Central, QLD, 4300, Australia.
Pharm Res. 2021 Sep;38(9):1477-1484. doi: 10.1007/s11095-021-03100-1. Epub 2021 Sep 3.
The evidence shows that individuals with type-1 diabetes mellitus (T1DM) are at greater risk of accelerated cognitive impairment and dementia. Although, to date the mechanisms are largely unknown. An emerging body of literature indicates that dysfunction of cerebral neurovascular network and plasma dyshomeostasis of soluble amyloid-β in association with impaired lipid metabolism are central to the onset and progression of cognitive deficits and dementia. However, the latter has not been extensively considered in T1DM. Therefore, in this review, we summarised the literature concerning altered lipid metabolism and cerebrovascular function in T1DM as an implication for potential pathways leading to cognitive decline and dementia.
研究表明，1 型糖尿病（T1DM）患者认知障碍和痴呆的风险更高。尽管迄今为止其机制仍不清楚。越来越多的文献表明，脑神经血管网络功能障碍和可溶性淀粉样蛋白-β的血浆失衡与脂质代谢受损是导致认知缺陷和痴呆的核心。然而，后者在 T1DM 中尚未得到广泛关注。因此，在这篇综述中，我们总结了 T1DM 中脂质代谢和脑血管功能改变的文献，探讨其与认知能力下降和痴呆相关的潜在途径。
