进化偶联范围在不同酶之间差异很大，这取决于选择压力。
Evolutionary coupling range varies widely among enzymes depending on selection pressure.
机构信息
Instituto de Ciencias Físicas, Escuela de Ciencia y Tecnología, Universidad Nacional de San Martín, San Martín, Buenos Aires, Argentina.
出版信息
Biophys J. 2021 Oct 19;120(20):4320-4324. doi: 10.1016/j.bpj.2021.08.042. Epub 2021 Sep 2.
Abstract
Recent studies proposed that enzyme-active sites induce evolutionary constraints at long distances. The physical origin of such long-range evolutionary coupling is unknown. Here, I use a recent biophysical model of evolution to study the relationship between physical and evolutionary couplings on a diverse data set of monomeric enzymes. I show that evolutionary coupling is not universally long-range. Rather, range varies widely among enzymes, from 2 to 20 Å. Furthermore, the evolutionary coupling range of an enzyme does not inform on the underlying physical coupling, which is short range for all enzymes. Rather, evolutionary coupling range is determined by functional selection pressure.
摘要
最近的研究表明，酶的活性位点在远距离上诱导进化约束。这种长程进化耦合的物理起源尚不清楚。在这里，我使用最近的进化生物物理模型来研究在各种单体酶的数据集上物理和进化耦合之间的关系。我表明，进化耦合并非普遍的长程。相反，酶之间的耦合范围差异很大，从 2 到 20Å 不等。此外，酶的进化耦合范围并不能反映潜在的物理耦合，所有酶的物理耦合范围都很短。相反，进化耦合范围是由功能选择压力决定的。
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