Department of Pharmacology, School of Medicine, Faculty of Health Sciences, University of the Free State, Bloemfontein, 9300 South Africa.
Department of Zoology, Fakir Mohan University, Vyasa Vihar, Balasore 756020 Odisha, India.
Curr Opin Pharmacol. 2021 Oct;60:261-267. doi: 10.1016/j.coph.2021.08.001. Epub 2021 Sep 1.
Ebola virus infection results in the fast onset of severe acute haemorrhagic fever with high mortality. The Ebola virus is labelled as a category A pathogen. Vaccines against the Ebola virus (EBOV) are essential for everyone, and an expansion in the arena of vaccine synthesis; especially, plant-based vaccine development has drawn attention. To express the heterologous protein for plant-based vectors, both RNA and DNA viruses have been adapted. Among the different approaches of plant-based vaccine technologies, the agroinfiltration method, which was initially established to investigate plant-virus interactions, has been considered an effective method to produce monoclonal antibodies against EBOV. The effectiveness of plants as bioreactors of vaccine/monoclonal antibodies development could be well-thought-out to attend the obligatory mandate. The review confers recent progress in the production of plant-based vaccines and antibody treatments against the Ebola virus disease, thereby alleviating public health alarms associated with EBOV.
埃博拉病毒感染会导致严重急性出血热迅速发作，死亡率高。埃博拉病毒被列为 A 类病原体。针对埃博拉病毒（EBOV）的疫苗对每个人都至关重要，疫苗合成领域不断扩大，特别是植物疫苗的发展引起了关注。为了表达植物载体的异源蛋白，已经适应了 RNA 和 DNA 病毒。在不同的植物疫苗技术方法中，最初建立的 agroinfiltration 方法是为了研究植物-病毒相互作用，被认为是生产针对 EBOV 的单克隆抗体的有效方法。植物作为疫苗/单克隆抗体开发的生物反应器的有效性可以很好地考虑到强制性要求。该综述介绍了针对埃博拉病毒病的植物疫苗和抗体治疗的最新进展，从而缓解了与埃博拉病毒相关的公共卫生警报。
