血液透析患者和肾移植患者中FGF23与贫血之间的关系。

The relationship between FGF23 and anemia in HD and renal transplant patients.

作者信息

Baloglu Ismail, Ozer Hakan, Ozturk Yasin, Erdur Mehmet Fatih, Tonbul Halil Zeki, Turkmen Kultigin

机构信息

Division of Nephrology, Department of Internal Medicine, Nigde Omer Halis Demir University Training and Research Hospital, 51100, Nigde, Turkey.

Division of Nephrology, Department of Internal Medicine, Necmettin Erbakan University Meram School of Medicine, Konya, Turkey.

出版信息

Int Urol Nephrol. 2022 May;54(5):1117-1122. doi: 10.1007/s11255-021-02982-9. Epub 2021 Sep 4.

DOI:10.1007/s11255-021-02982-9

PMID:34482498

Abstract

PURPOSE

Recent studies claim that FGF23 is also associated with anemia and inflammation. In this study, the relationship between FGF23 and anemia in hemodialysis (HD) and renal transplantation patients (RTx patients) patients was investigated.

METHODS

This was a cross-sectional study involving 40 RTx patients (13 females, 27 males; mean age, 45.93 ± 12.49 years) who had transplantation at least 6 months before, 25 HD patients (12 females, 13 males; mean age, 54.72 ± 15.5 years), and 20 healthy control subjects (13 females, 7 males; mean age, 36.7 ± 9.38 years). FGF23 was studied using Elisa method. Parameters such as iron, ferritin, total iron binding capacity, and transferrin saturation were assessed.

RESULTS

FGF23 level was significantly higher in HD patients when compared with the RTx patients and control groups. In the bivariate correlation analysis, hemoglobin was positively correlated with albumin (r = 0.681, p = 0.000), ferritin (r = 0.446, p = 0.043), and negatively correlated with CRP (r = - 0.476, p = 0.016) and FGF23 (r = 0.493, p = 0.043). FGF23 was found to be an independent predictor of decreased hemoglobin in HD patients. In addition, this association was observed to disappear after transplantation.

CONCLUSION

While FGF23 is closely related to hemoglobin levels in HD patients, we have shown that this relationship disappears after transplantation.

摘要

目的

近期研究表明，成纤维细胞生长因子23（FGF23）也与贫血和炎症相关。本研究调查了FGF23与血液透析（HD）患者及肾移植患者（RTx患者）贫血之间的关系。

方法

这是一项横断面研究，纳入了40例至少在6个月前接受移植的RTx患者（13例女性，27例男性；平均年龄45.93±12.49岁）、25例HD患者（12例女性，13例男性；平均年龄54.72±15.5岁）以及20例健康对照者（13例女性，7例男性；平均年龄36.7±9.38岁）。采用酶联免疫吸附测定（ELISA）法检测FGF23。评估铁、铁蛋白、总铁结合力和转铁蛋白饱和度等参数。

结果

与RTx患者和对照组相比，HD患者的FGF23水平显著更高。在双变量相关性分析中，血红蛋白与白蛋白呈正相关（r = 0.681，p = 0.000）、与铁蛋白呈正相关（r = 0.446，p = 0.043），与C反应蛋白（CRP）呈负相关（r = -0.476，p = 0.016）以及与FGF23呈负相关（r = 0.493，p = 0.043）。FGF23被发现是HD患者血红蛋白降低的独立预测因素。此外，这种关联在移植后消失。