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氰基丙烯酸酯对诱导跟腱断裂兔的影响。

Effects of Cyanoacrylate in Rabbits with Induced Achilles Tendon Rupture.

机构信息

Department of Orthopaedics and Traumatology, Trabzon Kanuni Training and Research Hospital, University of Health Sciences, Trabzon, Turkey.

Department of Orthopaedics and Traumatology, Faculty of Medicine, University of Ordu, Ordu, Turkey.

出版信息

Med Sci Monit. 2021 Sep 6;27:e929709. doi: 10.12659/MSM.929709.

DOI:10.12659/MSM.929709
PMID:34483334
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8434771/
Abstract

BACKGROUND In this study, we aimed to investigate the effects of N-butyl-2-cyanoacrylate (cyanoacrylate) on the biomechanical and histopathological aspects of tendon healing in a rabbit model of Achilles tendon injury. MATERIAL AND METHODS In total, 36 rabbits were randomized to experimental (cyanoacrylate) and control groups (n=36 tendons in each group). A simple suture was used in the control group and a simple suture plus cyanoacrylate was used in the experimental group. Nine rabbits from each group were euthanized at week 4 and week 6 after surgery for histopathological and biomechanical testing. RESULTS Granulation tissue formation was significantly greater in the experimental group in week 4 and week 6 than in the control group. Foreign body giant cell formation was significantly higher in the experimental group in week 4 and week 6. The maximum rupture force was significantly higher in the experimental group in week 4 and week 6 than in the control group. Elasticity and stiffness were comparable between groups in week 4; however, stiffness, but not elasticity, was significantly higher in the experimental group in week 6. CONCLUSIONS In the short term, cyanoacrylate enhanced tendon endurance in both a histopathological and biomechanical manner. We conclude that the early initiation of rehabilitation in patients may be safe in cases of cyanoacrylate use for surgical repair of tendon injury.

摘要

背景

在这项研究中，我们旨在研究 N-丁基-2-氰基丙烯酸酯（氰基丙烯酸酯）对兔跟腱损伤模型中肌腱愈合的生物力学和组织病理学方面的影响。

材料和方法

共有 36 只兔子随机分为实验组（氰基丙烯酸酯）和对照组（每组 36 根肌腱）。对照组采用单纯缝合，实验组采用单纯缝合加氰基丙烯酸酯。每组各有 9 只兔子在术后第 4 周和第 6 周处死进行组织病理学和生物力学测试。

结果

实验组在第 4 周和第 6 周时肉芽组织形成明显多于对照组。实验组在第 4 周和第 6 周时异物巨细胞形成明显高于对照组。实验组在第 4 周和第 6 周时最大断裂力明显高于对照组。实验组在第 4 周时的弹性和刚度与对照组相当；然而，实验组在第 6 周时的刚度明显高于对照组，但弹性没有差异。

结论

短期内，氰基丙烯酸酯在组织病理学和生物力学方面均增强了肌腱的耐久性。我们的结论是，在使用氰基丙烯酸酯修复肌腱损伤的情况下，早期开始康复治疗对患者来说可能是安全的。

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