一例复发性疼痛性眼肌麻痹性神经病经β受体阻滞剂滴眼液滴眼治疗成功的病例
A Case of Recurrent Painful Ophthalmoplegic Neuropathy Successfully Treated with Beta-blocker Eye Drop Instillation.
作者信息
Takemoto Daisuke, Ohkubo Shinji, Udagawa Sachiko, Kuroda Mondo, Sugiyama Kazuhisa
机构信息
Department of Ophthalmology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan.
Ohukubo Eye Clinic, Kanazawa, Japan.
出版信息
Neuroophthalmology. 2020 Jul 22;45(5):320-323. doi: 10.1080/01658107.2020.1791190. eCollection 2021.
Recurrent painful ophthalmoplegic neuropathy (RPON) is a rare disorder, which typically occurs in children, and causes headaches and unilateral oculomotor palsy. Early high-dose corticosteroid therapy is recommended to rapidly resolve acute episodes. However, the pathophysiology and therapeutic options for this disorder remain to be fully elucidated. We report a case with typical clinical features of RPON successfully treated with beta-blocker eye drop instillation after the effects of high-dose corticosteroid and other therapies were not sufficient. We propose that beta-blocker eye drop instillation should be considered for patients with corticosteroid-resistant RPON.
复发性疼痛性眼肌麻痹性神经病变（RPON）是一种罕见疾病，通常发生于儿童，可导致头痛和单侧动眼神经麻痹。建议早期采用大剂量皮质类固醇疗法以迅速缓解急性发作。然而，该疾病的病理生理学及治疗选择仍有待充分阐明。我们报告了1例具有RPON典型临床特征的病例，在大剂量皮质类固醇及其他疗法效果不佳后，经滴注β受体阻滞剂滴眼液成功治愈。我们建议，对于皮质类固醇抵抗的RPON患者，应考虑使用β受体阻滞剂滴眼液进行治疗。
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