Bilal Muhammad, Ahmad Saeed, Rehman Tayyeba, Ghauri Aymen Owais, Khalid Sana, Abbasi Waheed Mumtaz, Zakki Shahbaz Ahmad
Faculty of Medicine and Allied Health Sciences, University College of Conventional Medicine, The Islamia University of Bahawalpur, Bahawalpur, Pakistan.
Faculty of Pharmacy, Department of Pharmaceutical Chemistry, The Islamia University of Bahawalpur, Bahawalpur, Pakistan.
Dose Response. 2021 Sep 1;19(3):15593258211040329. doi: 10.1177/15593258211040329. eCollection 2021 Jul-Sep.
Hyperuricemia is a metabolic disorder with characteristic elevated serum uric acid. Recently, several plant-based medicines are being used for the treatment of hyperuricemia. The study aimed to find the hypouricemic potential of in and study models. In studies, xanthine oxidase inhibition assay was performed to evaluate IC value and capsule absorbance of the drug, respectively. For experiment, the study comprised 15 groups of rats. results revealed that significant xanthine oxidase inhibition was shown by with an IC value of 272.73±.3 μg/mL. Similarly, oral administration of with dosages of 250 and 500 mg/kg decreased serum and liver uric acid levels significantly in a dose- and time-dependent manner in oxonate-induced hyperuricemic rats. Furthermore, 3-day and 7-day administration of showed more potential compared to 1-day administrations. The present study indicated marked hypouricemic effects of in rats. Due to caveat of the small sample size, a firm assumption of the hypouricemic effect of cannot be made. However, extensive study is needed to find out the exact molecular mechanism involved and to translate its effects into clinical trials for the further validation of the results.
高尿酸血症是一种以血清尿酸升高为特征的代谢紊乱疾病。最近，几种植物性药物被用于治疗高尿酸血症。该研究旨在在[具体研究对象1]和[具体研究对象2]研究模型中发现[药物名称]的降尿酸潜力。在[具体研究1]中，分别进行黄嘌呤氧化酶抑制试验以评估药物的IC值和胶囊吸光度。对于[具体实验]，该研究包括15组大鼠。[实验]结果显示，[药物名称]表现出显著的黄嘌呤氧化酶抑制作用，IC值为272.73±[X]μg/mL。同样，在氧嗪酸钾诱导的高尿酸血症大鼠中，口服剂量为250和500mg/kg的[药物名称]以剂量和时间依赖性方式显著降低血清和肝脏尿酸水平。此外，与1天给药相比，[药物名称]3天和7天给药显示出更大的潜力。本研究表明[药物名称]在大鼠中具有显著的降尿酸作用。由于样本量小的限制，不能对[药物名称]的降尿酸作用做出确凿的假设。然而，需要进行广泛的研究以找出其中的确切分子机制，并将其作用转化为临床试验以进一步验证结果。
