Anti-Hyperuricemic and Uricosuric Potential of in Oxonate-Induced Hyperuricemic Rats.

Hyperuricemia is a metabolic disorder with characteristic elevated serum uric acid. Recently, several plant-based medicines are being used for the treatment of hyperuricemia. The study aimed to find the hypouricemic potential of in and study models. In studies, xanthine oxidase inhibition assay was performed to evaluate IC value and capsule absorbance of the drug, respectively. For experiment, the study comprised 15 groups of rats. results revealed that significant xanthine oxidase inhibition was shown by with an IC value of 272.73±.3 μg/mL. Similarly, oral administration of with dosages of 250 and 500 mg/kg decreased serum and liver uric acid levels significantly in a dose- and time-dependent manner in oxonate-induced hyperuricemic rats. Furthermore, 3-day and 7-day administration of showed more potential compared to 1-day administrations. The present study indicated marked hypouricemic effects of in rats. Due to caveat of the small sample size, a firm assumption of the hypouricemic effect of cannot be made. However, extensive study is needed to find out the exact molecular mechanism involved and to translate its effects into clinical trials for the further validation of the results.