Fontaine Christina, Papworth Emma, Pascoe John, Hashim Hashim
Specialist Registrar in Urology, University Hospitals Plymouth, Derriford Road, Devon, PL6 8AU, UK.
Bristol Urological Institute, Southmead Hospital, Bristol, Somerset, UK.
Ther Adv Urol. 2021 Aug 31;13:17562872211039034. doi: 10.1177/17562872211039034. eCollection 2021 Jan-Dec.
Overactive bladder (OAB) syndrome is a common condition characterised by urinary urgency, with or without urgency incontinence, frequency and nocturia, in the absence of any other pathology. Clinical diagnosis is based upon patient self-reported symptomology. Currently there is a plethora of treatments available for the management of OAB. Clinical guidelines suggest treatment a multidisciplinary pathway including behavioural therapy and pharmacotherapy, which can be commenced in primary care, with referral to specialist services in those patients refractory to these treatments. Intradetrusor botulinum A and sacral neuromodulation provide safe and efficacious management of refractory OAB. Percutaneous tibial nerve stimulation and augmentation cystoplasty remain available and efficacious in a select group of patients. Unfortunately, there remains a high rate of patient dissatisfaction and discontinuation in all treatments and thus there remains a need for emerging therapies in the management of OAB.
膀胱过度活动症(OAB)综合征是一种常见病症,其特征为尿急,伴有或不伴有急迫性尿失禁、尿频和夜尿症,且不存在任何其他病理状况。临床诊断基于患者自我报告的症状。目前有大量治疗方法可用于管理OAB。临床指南建议采用多学科治疗途径,包括行为疗法和药物疗法,这些治疗可在初级保健中开始,对于那些对这些治疗无效的患者可转诊至专科服务。膀胱逼尿肌内注射肉毒杆菌毒素A和骶神经调节为难治性OAB提供了安全有效的管理方法。经皮胫神经刺激和膀胱扩大成形术在特定患者群体中仍然可用且有效。不幸的是,所有治疗中患者的不满率和停药率仍然很高,因此在OAB的管理中仍需要新出现的治疗方法。