Mao Haiyan, Lin Tong, Huang Shanshan, Xie Zhenye, Chen Zhikui
Department of Critical Care Medicine, Ningbo Medical Center Lihuili Hospital, Ningbo, China.
Cardiovascular Medicine, Ningbo Medical Center Lihuili Hospital, Ningbo, China.
Front Endocrinol (Lausanne). 2025 Apr 15;16:1541218. doi: 10.3389/fendo.2025.1541218. eCollection 2025.
The triglyceride glucose-waist height ratio (TyG-WHtR) index is a useful marker for predicting the risk of cardiovascular and metabolic diseases. Metabolic diseases are known to be high-risk factors for overactive bladder (OAB). However, no studies have explored the association between the TyG-WHtR index and the risk of developing OAB.
Data from the National Health and Nutrition Examination Survey (NHANES) was utilized, and a weighted multivariate logistic regression analysis was conducted to investigate the relationship between TyG-WHtR and OAB. Subgroup analyses and interaction tests were also performed. Additionally, sensitivity analyses were conducted to validate the robustness of the findings. A smooth curve fitting and threshold effect analysis explored the nonlinear relationship between TyG-WHtR and the risk of developing OAB. The predictive value of the TyG-WHtR index for OAB was assessed using Receiver Operating Characteristic (ROC) curves, and the area under the ROC curve (AUC) was calculated.
A total of 14,652 adults aged 20 and above were included in this study. After weighting, the population size was estimated to be 197,598,146.7, among which 37,872,284.55 individuals were diagnosed with OAB. The median TyG-WHtR for the entire population was 4.98, while it was 5.44 for those with OAB. Weighted logistic regression analysis revealed a significant positive association between TyG-WHtR and the occurrence of OAB (OR=1.646; 95% CI: 1.562, 1.735; <0.001). This positive association remained significant even after adjusting for confounding factors (OR=1.310; 95% CI: 1.157, 1.484; <0.001). Sensitivity analysis demonstrated the robustness of the results. Subgroup and interaction analyses indicated that the impact of the TyG-WHtR index on OAB might be influenced by gender (OR=1.323; 95% CI: 1.138, 1.538; <0.001) and age (OR=1.426; 95% CI: 1.180, 1.724; <0.001). Smooth curve fitting and threshold effect analysis revealed a threshold of 3.579. ROC curve analysis demonstrated that the TyG-WHtR index has a good predictive ability for OAB (AUC=0.647; 95% CI: 0.636, 0.657).
The TyG-WHtR index is significantly positively associated with the occurrence of OAB and could potentially serve as a novel risk predictor for OAB. Future research is needed to validate findings, explore causality, and improve early detection through multifactorial models across diverse populations.
甘油三酯葡萄糖-腰围身高比（TyG-WHtR）指数是预测心血管和代谢疾病风险的有用指标。已知代谢疾病是膀胱过度活动症（OAB）的高危因素。然而，尚无研究探讨TyG-WHtR指数与OAB发病风险之间的关联。
利用美国国家健康与营养检查调查（NHANES）的数据，进行加权多因素逻辑回归分析，以研究TyG-WHtR与OAB之间的关系。还进行了亚组分析和交互作用检验。此外，进行敏感性分析以验证研究结果的稳健性。通过平滑曲线拟合和阈值效应分析探索TyG-WHtR与OAB发病风险之间的非线性关系。使用受试者工作特征（ROC）曲线评估TyG-WHtR指数对OAB的预测价值，并计算ROC曲线下面积（AUC）。
本研究共纳入14652名20岁及以上成年人。加权后，估计总体规模为197598146.7，其中37872284.55人被诊断为OAB。整个人群的TyG-WHtR中位数为4.98，而OAB患者为5.44。加权逻辑回归分析显示TyG-WHtR与OAB的发生之间存在显著正相关（OR = 1.646；95% CI：1.562，1.735；P < 0.001）。即使在调整混杂因素后，这种正相关仍然显著（OR = 1.310；95% CI：1.157，1.484；P < 0.001）。敏感性分析证明了结果的稳健性。亚组和交互分析表明，TyG-WHtR指数对OAB的影响可能受性别（OR = 1.323；95% CI：1.138，1.538；P < 0.001）和年龄（OR = 1.426；95% CI：1.180，1.724；P < 0.001）影响。平滑曲线拟合和阈值效应分析显示阈值为3.579。ROC曲线分析表明，TyG-WHtR指数对OAB具有良好的预测能力（AUC = 0.647；95% CI：0.636，0.657）。
TyG-WHtR指数与OAB的发生显著正相关，可能作为OAB的新型风险预测指标。未来需要进一步研究以验证研究结果、探索因果关系，并通过跨不同人群的多因素模型改善早期检测。
