Moore L R, Chang S F, Greenstein E T
Controlled Drug Delivery Research Center, College of Pharmacy, Rutgers-State University of New Jersey, Piscataway.
Methods Find Exp Clin Pharmacol. 1987 Nov;9(11):711-5.
Stable long-term anesthesia in the rabbit (greater than 8 hr) has been achieved by the administration of urethane and acepromazine. Twenty-five healthy male New Zealand white rabbits weighing 2 to 4 kg were used for this study. Two groups of animals were studied. The first group of 11 rabbits received urethane (1.0 g/kg) and acepromazine (1 mg/0.46 kg). This resulted in stable light plane anesthesia for 13.5 +/- 4.5 hr (mean + S.D.). The second group of 14 rabbits received urethane (1.3 g/kg) and acepromazine (1 mg/0.46 kg) which resulted in deep plane anesthesia for 23.0 +/- 4 hr. Heart rate and respiratory rate remained stable throughout the entire period and all animals were alert and without any observable side effects by 48 +/- 3 hr. This study indicates that the combination of urethane-acepromazine is a safe and reproducible parenteral anesthetic that may be used in studies of long duration in rabbits.
通过给予乌拉坦和乙酰丙嗪，已在兔身上实现了稳定的长期麻醉（超过8小时）。本研究使用了25只体重2至4千克的健康雄性新西兰白兔。对两组动物进行了研究。第一组11只兔子接受了乌拉坦（1.0克/千克）和乙酰丙嗪（1毫克/0.46千克）。这导致了13.5±4.5小时（平均值±标准差）的稳定浅麻醉平面。第二组14只兔子接受了乌拉坦（1.3克/千克）和乙酰丙嗪（1毫克/0.46千克），这导致了23.0±4小时的深麻醉平面。在整个期间，心率和呼吸频率保持稳定，所有动物在48±3小时时都很警觉，没有任何可观察到的副作用。这项研究表明，乌拉坦 - 乙酰丙嗪组合是一种安全且可重复的非肠道麻醉剂，可用于兔的长期研究。
