高敏心肌肌钙蛋白T是主要不良心血管事件和全因死亡率的危险因素：一项9.5年的随访研究。
High-Sensitivity Cardiac Troponin T Is a Risk Factor for Major Adverse Cardiovascular Events and All-Cause Mortality: A 9.5-Year Follow-Up Study.
作者信息
Wang Xiaona, Wang Peiqi, Cao Ruihua, Yang Xu, Xiao Wenkai, Zhang Yun, Sheng Li, Ye Ping
机构信息
Department of Geriatric Cardiology, The Second Medical Center and National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, China.
Department of Anesthesiology, The First Medical Center, Chinese PLA General Hospital, Beijing, China.
出版信息
Cardiol Res Pract. 2021 Aug 25;2021:6647987. doi: 10.1155/2021/6647987. eCollection 2021.
BACKGROUND
The relationship between high-sensitivity cardiac troponin T (hs-cTnT) and different cardiovascular events has been observed in several large community studies, and the results have been controversial. However, there is currently no cross-sectional or longitudinal follow-up study on hs-cTnT in the Chinese population.
METHODS
We analyzed the association of plasma hs-cTnT levels with major adverse cardiovascular events (MACEs) and all-cause mortality in 1325 subjects from a longitudinal follow-up community-based population in Beijing, China.
RESULTS
In the Cox proportional hazards models analysis, the risk of MACEs increased with the increase of hs-cTnT levels (HR, 1.223, 95% CI, 1.054-1.418, =0.008). Increased hs-cTnT levels were associated with coronary events (HR, 1.391, 95% CI, 1.106-1.749, =0.005) in Model 4. Cox proportional risk regression model analysis revealed that increased hs-cTnT levels were associated with an increased risk of mortality (HR, 1.763, 95% CI, 1.224-2.540, =0.002), even after adjusting hs-CRP and NT-proBNP. The area under the ROC curve for predicting MACEs was 0.559 (95% CI, 0.523-0.595, =0.001). The areas under the ROC curve for predicting coronary events and mortality were 0.629 (95% CI, 0.580-0.678, < 0.001) and 0.644 (95% CI, 0.564-0.725, < 0.001), respectively.
CONCLUSIONS
Our findings in the Chinese cohort support that hs-cTnT is a risk factor for major adverse cardiovascular events and all-cause mortality.
背景
在多项大型社区研究中观察到了高敏心肌肌钙蛋白T（hs-cTnT）与不同心血管事件之间的关系，但其结果存在争议。然而，目前在中国人群中尚无关于hs-cTnT的横断面或纵向随访研究。
方法
我们分析了来自中国北京一个基于社区的纵向随访人群的1325名受试者血浆hs-cTnT水平与主要不良心血管事件（MACE）及全因死亡率之间的关联。
结果
在Cox比例风险模型分析中，MACE的风险随着hs-cTnT水平的升高而增加（HR=1.223，95%CI为1.054-1.418，P=0.008）。在模型4中，hs-cTnT水平升高与冠状动脉事件相关（HR=1.391，95%CI为1.106-1.749，P=0.005）。Cox比例风险回归模型分析显示，即使在调整了hs-CRP和NT-proBNP后，hs-cTnT水平升高仍与死亡风险增加相关（HR=1.763，95%CI为1.224-2.540，P=0.002）。预测MACE的ROC曲线下面积为0.559（95%CI为0.523-0.595，P=0.001）。预测冠状动脉事件和死亡率的ROC曲线下面积分别为0.629（95%CI为0.580-0.678，P<0.001）和0.644（95%CI为0.564-0.725，P<0.001）。
结论
我们在中国队列中的研究结果支持hs-cTnT是主要不良心血管事件和全因死亡率的危险因素。
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