Messaoudi N, Bouichrat N, Karrou M, Assarrar I, Malki S, Elmahjoubi S, Rouf S, Karich N, Lachkar A, Sefiani S, Bouziane M, Kamaoui I, Latrech H
Department of Endocrinology-Diabetology and Nutrition, Mohammed VI University Hospital Center, Faculty of Medicine and Pharmacy, University of Mohammed 1st, Oujda, Morocco.
Department of Anatomical Pathology, Mohammed VI University Hospital Center, Faculty of Medicine and Pharmacy, University of Mohammed 1st, Oujda, Morocco.
Case Rep Endocrinol. 2021 Aug 27;2021:4870493. doi: 10.1155/2021/4870493. eCollection 2021.
Adrenal adenolipomas are rare lipomatous adrenal tumors that can be either functional or not. Only 7 cases have been reported in the English literature so far. However, brown tumors are benign, rare, historical lesions, with histological similarity to giant tumors that can be encountered in 1% of all primary hyperparathyroidism cases. We report the case of an unusual association of bilateral lipoadenoma of the adrenal glands and humeral brown tumor in a 35-year-old patient. He presented to the emergency department with a pathological fracture of the left humerus secondary to a brown tumor. The medical investigations have concluded to primary hyperparathyroidism. The screening for multiple endocrine neoplasia type 1 revealed the presence of bilateral nonsecreting adrenal masses whose anatomopathological study concluded adenolipomas. Adrenal tumors may constitute a part of multiple endocrine neoplasia type 1 in 20 to 40% of cases. In this view, it is necessary to check for the presence of other endocrine gland tumor locations such as primary hyperparathyroidism, neuroendocrine tumors of the duodenum and pancreas, or pituitary adenomas.
肾上腺腺脂肪瘤是一种罕见的肾上腺脂肪瘤性肿瘤，可为功能性或无功能性。迄今为止，英文文献中仅报道了7例。然而，棕色瘤是良性、罕见的既往病变，在组织学上与所有原发性甲状旁腺功能亢进病例中1%可能出现的巨细胞瘤相似。我们报告了一名35岁患者肾上腺双侧脂肪瘤和肱骨棕色瘤罕见关联的病例。他因棕色瘤继发左肱骨病理性骨折就诊于急诊科。医学检查诊断为原发性甲状旁腺功能亢进。对多发性内分泌腺瘤1型的筛查发现双侧无分泌功能的肾上腺肿块，经解剖病理学研究诊断为腺脂肪瘤。在20%至40%的病例中，肾上腺肿瘤可能是多发性内分泌腺瘤1型的一部分。因此，有必要检查是否存在其他内分泌腺肿瘤部位，如原发性甲状旁腺功能亢进、十二指肠和胰腺的神经内分泌肿瘤或垂体腺瘤。
