Manusov Eron G, Gomez De Ziegler Carolina, Diego Vincent P, Munoz-Monaco Gerardo, Williams-Blangero Sarah
Department of Human Genetics, School of Medicine, University of Texas Rio Grande Valley, Edinburg, TX, United States.
Knapp Family Medicine Residency Program, University of Texas Rio Grande Valley, Edinburg, TX, United States.
Front Med (Lausanne). 2021 Aug 18;8:650259. doi: 10.3389/fmed.2021.650259. eCollection 2021.
Frailty is the age-related decline in well-being. The Frailty index (FI) measures the accumulation of health deficits and reflects biopsychosocial and cultural determinants of well-being. Frailty is measured as a static phenotype or as a Frailty Index comprising a ratio of suffered health deficits and total deficits. We report a Frailty Index calculated from routinely measured clinical variables gathered from residents of two Colonias (neighborhoods) in South Texas. A Colonia is a predominantly Hispanic, economically distressed, unincorporated neighborhood. We analyzed retrospective data from 894 patients that live in two Colonias located on the Texas-Mexico border. We calculated the FI with seven physiological variables, PHQ-9 score, and the 11 domain-specific Duke Profile scores, for a total of 19 possible health deficits. FI against age separately in males ( = 272) and females ( = 622) was regressed. Females had a significantly higher starting frailty, and males had a significantly greater change rate with age. FI against age for Cameron Park Colonia and Indian Hills Colonia was regressed. We calculated a significantly higher starting FI in Indian Hills and a significantly greater change rate in Cameron Park residents. Frailty's contributors are complex, especially in neighborhoods of poverty, immigration, low education level, and high prevalence of chronic disease. We report baseline Frailty Index data from two Colonias in South Texas and the clinical and research implications.
衰弱是与年龄相关的健康状况下降。衰弱指数（FI）衡量健康缺陷的累积情况，并反映健康状况的生物心理社会和文化决定因素。衰弱可作为一种静态表型来衡量，也可作为一个由遭受的健康缺陷与总缺陷之比组成的衰弱指数来衡量。我们报告了一个基于从南德克萨斯两个聚居区（社区）居民常规测量的临床变量计算得出的衰弱指数。聚居区是一个主要为西班牙裔、经济贫困的非建制社区。我们分析了居住在德克萨斯 - 墨西哥边境两个聚居区的894名患者的回顾性数据。我们用七个生理变量、PHQ - 9评分和11个特定领域的杜克概况评分来计算FI，总共19个可能的健康缺陷。分别对男性（ = 272）和女性（ = 622）的FI与年龄进行回归分析。女性的初始衰弱程度显著更高，而男性随年龄增长的变化率显著更大。对卡梅伦公园聚居区和印第安山聚居区的FI与年龄进行回归分析。我们计算得出印第安山的初始FI显著更高，而卡梅伦公园居民的变化率显著更大。衰弱的影响因素很复杂，尤其是在贫困、移民、低教育水平和慢性病高患病率的社区。我们报告了南德克萨斯两个聚居区的基线衰弱指数数据以及临床和研究意义。
