病例报告：严重胎盘血栓栓塞相关的新型冠状病毒母婴传播及胎儿死亡
Case Report: SARS-CoV-2 Mother-to-Child Transmission and Fetal Death Associated With Severe Placental Thromboembolism.
作者信息
Marinho Penélope Saldanha, da Cunha Antonio José Ledo Alves, Chimelli Leila, Avvad-Portari Elyzabeth, Andreiuolo Felipe da Matta, de Oliveira-Szejnfeld Patrícia Soares, Mendes Mayara Abud, Gomes Ismael Carlos, Souza Letícia Rocha Q, Guimarães Marilia Zaluar, Goldman Suzan Menasce, de Oliveira Mariana Barros Genuíno, Rehen Stevens, Amim Joffre, Tovar-Moll Fernanda, Prata-Barbosa Arnaldo
机构信息
Maternity School, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Department of Pediatrics, D'Or Institute for Research and Education, Rio de Janeiro, Brazil.
出版信息
Front Med (Lausanne). 2021 Aug 16;8:677001. doi: 10.3389/fmed.2021.677001. eCollection 2021.
SARS-CoV-2 infection during pregnancy is not usually associated with significant adverse effects. However, in this study, we report a fetal death associated with mild COVID-19 in a 34-week-pregnant woman. The virus was detected in the placenta and in an unprecedented way in several fetal tissues. Placental abnormalities (MRI and anatomopathological study) were consistent with intense vascular malperfusion, probably the cause of fetal death. Lung histopathology also showed signs of inflammation, which could have been a contributory factor. Monitoring inflammatory response and coagulation in high-risk pregnant women with COVID-19 may prevent unfavorable outcomes, as shown in this case.
孕期感染严重急性呼吸综合征冠状病毒2（SARS-CoV-2）通常不会产生显著不良反应。然而，在本研究中，我们报告了一名34周妊娠的女性，其感染轻度2019冠状病毒病（COVID-19）后出现了胎儿死亡。在胎盘以及前所未有的几种胎儿组织中检测到了该病毒。胎盘异常（磁共振成像和解剖病理学研究）与严重的血管灌注不良一致，这可能是胎儿死亡的原因。肺部组织病理学也显示出炎症迹象，这可能是一个促成因素。正如本病例所示，对COVID-19高危孕妇监测炎症反应和凝血情况可能会预防不良后果。
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