An overview of surface-enhanced Raman scattering substrates by pulsed laser deposition technique: fundamentals and applications.

Metallic nanoparticles (NPs), as an efficient substrate for surface-enhanced Raman scattering (SERS), attract much interests because of their various shapes and sizes. The appropriate size and morphology of metallic NPs are critical to serve as the substrate for achieving an efficient SERS. Pulsed laser deposition (PLD) is one of the feasible physical methods employed to synthesize metallic NPs with controllable sizes and surface characteristics. It has been recognized to be a successful tool for the deposition of SERS substrates due to its good controllability and high reproducibility in the manufacture of metallic NPs. This review provides an overview about the recent advances for the preparation of SERS substrates by PLD technique. The influences of parameters on the sizes and morphologies of metallic NPs during the deposition processes in PLD technique including laser output parameters, gas medium, liquid medium, substrate temperature, and properties of 3D substrate are presented. The applications of SERS substrates produced by PLD in the environmental monitoring and biomedical analysis are summarized. This knowledge could serve as a guideline for the researchers in exploring further applications of PLD technique in the production of SERS substrate.