USP5 通过促进 NLRP3 的自噬降解来减弱 NLRP3 炎症小体的激活。
USP5 attenuates NLRP3 inflammasome activation by promoting autophagic degradation of NLRP3.
机构信息
Key Laboratory of Infection and Immunity of Shandong Province & Department of Immunology, School of Biomedical Sciences, Shandong University, Jinan, China.
Department of Pharmacology, School of Biomedical Sciences, Shandong University, Jinan, China.
出版信息
Autophagy. 2022 May;18(5):990-1004. doi: 10.1080/15548627.2021.1965426. Epub 2021 Sep 5.
Abstract
3-MA: 3-methyladenine; AIM2: absent in melanoma 2; ATG5: autophagy related 5; BafA1: bafilomycin A; CASP1: caspase 1; CHX: cycloheximide; Co-IP: co-immunoprecipitation; CQ: chloroquine; DUBs: deubiquitinases; IL1B/IL-1β: interleukin 1 beta; LAMP1: lysosomal associated membrane protein 1; LPS: lipopolysaccharide; MARCHF7/MARCH7: membrane associated RING-CH-type finger 7; NFKB/NF-κB: nuclear factor kappa B; Nig.: nigericin; NLRC4: NLR family CARD domain containing 4; NLRP3: NLR family pyrin domain containing 3; PECs: peritoneal exudate cells; PMN: polymorphonuclear; PMs: peritoneal macrophages; PYCARD/ASC: PYD and CARD domain containing; TLRs: toll like receptors; TNF/TNF-α: tumor necrosis factor; Ub: ubiquitin; USP5: ubiquitin specific peptidase 5; WT: wild type.
摘要
3-MA：3-甲基腺嘌呤；AIM2：黑色素瘤 2 中缺失；ATG5：自噬相关 5；BafA1：巴弗洛霉素 A；CHX：环己酰亚胺；Co-IP：免疫共沉淀；CQ：氯喹；DUBs：去泛素化酶；IL1B/IL-1β：白细胞介素 1β；LAMP1：溶酶体相关膜蛋白 1；LPS：脂多糖；MARCHF7/MARCH7：膜相关 RING-CH 型指状蛋白 7；NFKB/NF-κB：核因子 kappa B；Nig.：尼格菌素；NLRC4：NLR 家族 CARD 结构域包含蛋白 4；NLRP3：NLR 家族吡咯烷结构域包含蛋白 3；PECs：腹腔渗出细胞；PMN：多形核；PMs：腹腔巨噬细胞；PYCARD/ASC：含有 PYD 和 CARD 结构域；TLRs： toll 样受体；TNF/TNF-α：肿瘤坏死因子；Ub：泛素；USP5：泛素特异性肽酶 5；WT：野生型。
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