使用芳基二硼前体进行面向硼中子俘获疗法的正电子发射断层显像（PET）探针[F]FBPA的亲核放射性合成。
Nucleophilic radiosynthesis of boron neutron capture therapy-oriented PET probe [F]FBPA using aryldiboron precursors.
作者信息
He Jing, Yan Heng, Du Yanrong, Ji Yan, Cai Fei, Fan Wenbin, Huo Li, Liu Yuan-Hao, Wang Zheng, Li Shihong
机构信息
Neuboron Medtech Ltd., No. 568 Longmian Ave, 211100, Nanjing, P. R. China.
JYAMS PET Research and Development Limited, No. 568 Longmian Ave, Nanjing, 211100, P. R. China.
出版信息
Chem Commun (Camb). 2021 Sep 6;57(71):8953-8956. doi: 10.1039/d1cc03369g.
A reliable copper-mediated nucleophilic radiosynthesis of the PET imaging probe [F]FBPA was developed using novel aryldiboron precursors. The carrier-free [F]FBPA with radiochemical purity >99% was prepared routinely the two-step synthesis with an automatic module and can be used for clinical PET imaging of tumours.
利用新型芳基二硼前体，开发了一种可靠的铜介导的亲核放射性合成PET成像探针[F]FBPA的方法。使用自动模块通过两步合成常规制备放射化学纯度>99%的无载体[F]FBPA，其可用于肿瘤的临床PET成像。
Zotero 插件