Chandra Girish, Pandey Ajay, Tipan Nilesh
Department of Mechanical Engineering, Maulana Azad National Institute of Technology, Bhopal, Madhya Pradesh, India.
Comput Methods Biomech Biomed Engin. 2022 May;25(6):603-618. doi: 10.1080/10255842.2021.1970145. Epub 2021 Sep 6.
In the current revolution of internal fixation implant in orthopaedics, a biodegradable implant is the most awaited and exceptional medical device where biodegradable material has paid more attention to the success of a biodegradable implant than the design of a biodegradable bone implant plate. By far, LCP is the most traditionally used implant plate (using non-biodegradable material) because of its experimental success, but not with qualified biodegradable material (Mg-alloy). This lack of mechanical performance is a major drawback that can be rectified by better structural design. This will help avoid few other problems as well. Therefore, with proper consideration, the LCP has been added to a semicircular filleted longitudinally centered embossed (LCE) structure to enhance overall mechanical performance that can help emphasize mechanical support even after continuous degradation when applied in a physiological environment. For mechanical verification of this advanced design of biodegradable bone implant plate, four-point bending test (4PBT) and axial compression test (ACT) have been performed using FEM on LCELCP, LCP, continuously degraded (CD)-LCELCP, and CD-LCP. LCELCP showed reduced stress of about 22% and 10% in 4PBT and ACT, respectively, compared to LCP. CD-LCELCP is safe during ACT over 6 months of continuous degradation when the degradation rate is assumed to be 4 mm/year. These results also ensured accuracy using mesh convergence and also mesh checked for quality assurance. Overall, LCELCP can be considered as a biodegradable bone implant plate because of its superior performance, if its ultimate validation is carried out through animal/human trials as future work.
在当前骨科内固定植入物的变革中，可生物降解植入物是最受期待且卓越的医疗设备，其中可生物降解材料对可生物降解植入物成功的关注度高于可生物降解骨植入板的设计。到目前为止，锁定加压接骨板（LCP）是最传统使用的植入板（使用不可生物降解材料），因其实验成功，但并非采用合格的可生物降解材料（镁合金）。这种机械性能的欠缺是一个主要缺点，可通过更好的结构设计加以纠正。这也将有助于避免其他一些问题。因此，经过适当考量，LCP已被添加到半圆形圆角纵向居中压纹（LCE）结构中，以增强整体机械性能，即使在生理环境中应用并持续降解后，仍有助于强化机械支撑。为了对这种先进的可生物降解骨植入板设计进行力学验证，已使用有限元法（FEM）对LCELCP、LCP、持续降解（CD）-LCELCP和CD-LCP进行了四点弯曲试验（4PBT）和轴向压缩试验（ACT）。与LCP相比，LCELCP在4PBT和ACT中分别显示出约22%和10%的应力降低。当假定降解速率为4毫米/年时，CD-LCELCP在长达6个月的持续降解的ACT过程中是安全的。这些结果还通过网格收敛确保了准确性，并对网格进行了质量保证检查。总体而言，如果通过动物/人体试验作为未来工作进行最终验证，由于其卓越性能，LCELCP可被视为一种可生物降解骨植入板。
