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AO/ASIF 33-C2型骨折双钢板接骨术中钛合金与可生物降解植入物的生物力学分析

Biomechanical analysis of titanium-alloy and biodegradable implants in dual plate osteosynthesis for AO/ASIF type 33-C2 fractures.

作者信息

Hu Mengmeng, Li Meng, Ma Rui, Li Xiaoya, Ren Xiaomeng, Du Longbo, Zeng Chuyang, Li Jiantao, Zhang Wei

机构信息

Senior Department of Orthopedics, the Fourth Medical Center of PLA General Hospital, No. 51 Fucheng Road, Beijing, 100048, China.

Hainan Hospital of PLA General Hospital, No.80 Jianglin Road, Sanya, Hainan Province, 572013, China.

出版信息

Heliyon. 2024 Feb 14;10(4):e26213. doi: 10.1016/j.heliyon.2024.e26213. eCollection 2024 Feb 29.

Abstract

BACKGROUND AND OBJECTIVE

Treating geriatric osteoporotic distal femur fractures has always presented challenges, but developing biodegradable materials has brought new opportunities for therapeutic intervention. Despite this progress, there currently needs to be more evidence-based biomechanical guidelines for using dual plate fixation and biodegradable materials in treating osteoporotic comminuted distal femoral fractures.In this study, finite element analysis was conducted to evaluate the mechanical effectiveness of different implant materials (titanium alloys, biodegradable materials, and combinations of both) in the fixation of physiological and osteoporotic distal femoral fractures.

METHODS

We constructed finite element models of 33-C2 fractures and three types of plates: the Lateral Less Invasive Stabilization System (LISS) plate, the titanium-alloy medial plate (TAP), and the biodegradable plate (BP). To evaluate the biomechanical advantages in both physiological femur (PF) and osteoporotic femur (OF) conditions, three scenarios were developed: LISS + TAP, LISS + BP, and double biodegradable plates (DBPs). Five loading conditions were applied to measure structural stiffness, fracture micromotion, and implant stress: medio-lateral four-point bending, antero-posterior four-point bending, axial loading, torsional loading, and sideways falling. Several parameters were examined, including peak Von Mises Stress (VMS) of the femur and lateral plate, maximum displacement, bending angle, torsional angle of fracture, and risk of fracture.

RESULTS

In four-point bending tests, the lateral plate of the DBPs group exhibited a slightly lower peak VMS compared to the LISS + TAP and LISS + BP groups. When subjected to axial loading, the stiffness values of the LISS + TAP (OF) were 1.42 times and 1.86 times higher than LISS + BP (OF) and DBPs (OF) groups, and the peak VMS of lateral plate of DBPs (OF) construct was approximately 2% and 16% lower than that of the LISS + TAP (OF) and LISS + BP (OF) constructs. Under torsional loading, DBPs (OF) demonstrated rotational stiffness that was respectively 2% and 52% greater than that of LISS + TAP (OF) and LISS + BP (OF). Regarding the peak VMS of femur, the values of DBPs (OF) were almost 8% and 15% lower than those of LISS + TAP (OF) and LISS + BP (OF).

CONCLUSIONS

The use of DBPs at 11.33 GPa facilitated early mobilization of load-bearing joints but exhibited limited ability to support full weight-bearing activities. Though LISS + TAP met practical strength requirements, one should consider the potential biological irritation and stress shielding. Thus, employing a combination of biodegradable and metal internal fixation is a valid approach to effectively treat weight-bearing joint fractures in clinical practice.

摘要

背景与目的

治疗老年骨质疏松性股骨远端骨折一直具有挑战性,但可生物降解材料的研发为治疗干预带来了新机遇。尽管取得了这一进展,但目前在骨质疏松性股骨远端粉碎性骨折的治疗中,使用双钢板固定和可生物降解材料仍缺乏基于证据的生物力学指南。在本研究中,进行了有限元分析,以评估不同植入材料(钛合金、可生物降解材料及其组合)在固定生理状态和骨质疏松性股骨远端骨折方面的力学效果。

方法

我们构建了33 - C2骨折以及三种类型钢板的有限元模型:外侧微创稳定系统(LISS)钢板、钛合金内侧钢板(TAP)和可生物降解钢板(BP)。为了评估在生理状态股骨(PF)和骨质疏松性股骨(OF)条件下的生物力学优势,设计了三种方案:LISS + TAP、LISS + BP和双可生物降解钢板(DBP)。应用五种加载条件来测量结构刚度、骨折微动和植入物应力:内外侧四点弯曲、前后四点弯曲、轴向加载、扭转加载和侧方跌倒。检查了几个参数,包括股骨和外侧钢板的峰值冯·米塞斯应力(VMS)、最大位移、弯曲角度、骨折扭转角度和骨折风险。

结果

在四点弯曲试验中,DBP组的外侧钢板峰值VMS略低于LISS + TAP组和LISS + BP组。在轴向加载时,LISS + TAP(OF)的刚度值分别比LISS + BP(OF)组和DBP(OF)组高1.42倍和1.86倍,DBP(OF)结构外侧钢板的峰值VMS分别比LISS + TAP(OF)和LISS + BP(OF)结构低约2%和16%。在扭转加载下,DBP(OF)的旋转刚度分别比LISS + TAP(OF)和LISS + BP(OF)大2%和52%。关于股骨的峰值VMS,DBP(OF)的值分别比LISS + TAP(OF)和LISS + BP(OF)低近8%和15%。

结论

使用11.33GPa的DBP有助于承重关节的早期活动,但在支持完全负重活动方面能力有限。虽然LISS + TAP满足实际强度要求,但应考虑潜在的生物刺激和应力遮挡。因此,在临床实践中采用可生物降解材料与金属内固定相结合的方法是有效治疗负重关节骨折的一种可行途径。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4f5/10884484/5410ef59e2ab/gr1.jpg

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