Department of Pharmacognosy, Facultyl of Pharmacy, Ardabil University of Medical Sciences, Ardabil, Iran.
Department of Traditional Pharmacy, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Nat Prod Res. 2022 Aug;36(16):4205-4209. doi: 10.1080/14786419.2021.1971977. Epub 2021 Sep 6.
Based on the long history of plants in east traditional medicines, several species of showed promising antioxidant, anti-inflammation and neuroprotection effects in pharmacological researches. Using bioassay-guided fractionation of various extract of , an endemic species that grows widely in Iran, based on on nitric oxide (NO) inhibitory activity against HO induced NO production in PC12 pheochromocytoma cells led to the isolation of two iridoid compounds namely, as 6β-hydroxy 8-epiboshnaloside () and 1,5,9-epideoxy loganic acid () and Verbascoside (). Finally, the interaction of isolated compounds with inducible nitric oxide synthase (iNOS) protein was simulated by molecular docking study. It is the first report of these two iridoid glycosides from spp. All three isolated compounds showed strong interaction with iNOS enzyme in molecular docking simulations. So, they possibly contributed in the NO inhibitory effect of .
基于植物在东方传统医学中的悠久历史，几种 显示出有希望的抗氧化、抗炎和神经保护作用的药理研究。利用生物测定指导的各种提取物的分馏，一种在伊朗广泛生长的特有物种，基于对诱导型一氧化氮合酶（iNOS）蛋白的相互作用进行了模拟。这是首次从 中分离出这两种环烯醚萜苷类化合物。所有三种分离出的化合物在分子对接模拟中均与 iNOS 酶表现出强烈的相互作用。因此，它们可能对 的 NO 抑制作用有贡献。
